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Oral antivirals for the prevention and treatment of SARS-CoV-2 infection.
Soriano, Vicente; de-Mendoza, Carmen; Edagwa, Benson; Treviño, Ana; Barreiro, Pablo; Fernandez-Montero, José V; Gendelman, Howard E.
  • Soriano V; UNIR Health Sciences School & Medical Center, Madrid, Spain.
  • de-Mendoza C; Department of Internal Medicine, Puerta de Hierro Research Institute and University Hospital, Madrid, Spain.
  • Edagwa B; Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska, Medical Center, NE, USA.
  • Treviño A; UNIR Health Sciences School & Medical Center, Madrid, Spain.
  • Barreiro P; Clinical Research Laboratory, Hospital Isabel Zendal, Madrid, Spain.
  • Fernandez-Montero JV; Infectious Diseases Unit, Hospital Son Llàtzer, Mallorca, Spain.
  • Gendelman HE; Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska, Medical Center, NE, USA.
AIDS Rev ; 24(1): 41-49, 2022 03 01.
Article in English | MEDLINE | ID: covidwho-1650093
ABSTRACT
Vaccines and antivirals are the classical weapons deployed to contain, prevent, and treat life-threatening viral illnesses. Specifically, for SARS-CoV-2 infection, vaccines protect against severe COVID-19 disease manifestations and complications. However, waning immunity and emergence of vaccine escape mutants remains a growing threat. This is highlighted by the current surge of the omicron COVID-19 variant. Thus, there is a race to find treatment alternatives. We contend that oral small molecule antivirals that halt SARSCoV- 2 infection are essential. Compared to currently available monoclonal antibodies and remdesivir, where parenteral administration is required, oral antivirals offer treatments in an outpatient setting with dissemination available on a larger scale. In response to this need at 2021's end, regulatory agencies provided emergency use authorization for both molnupiravir and nirmatrelvir. These medicines act on the viral polymerase and protease, respectively. Each is given for 5 days and can reduce disease progression by 30% and 89%, respectively. The advent of additional oral antivirals, the assessment of combination therapies, the formulation of extended-release medications, and their benefit for both early treatment and prophylaxis will likely transform the landscape of the COVID-19 pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: HIV Infections / COVID-19 Drug Treatment Topics: Vaccines / Variants Limits: Humans Language: English Journal: AIDS Rev Journal subject: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Year: 2022 Document Type: Article Affiliation country: AIDSRev.22000001

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Full text: Available Collection: International databases Database: MEDLINE Main subject: HIV Infections / COVID-19 Drug Treatment Topics: Vaccines / Variants Limits: Humans Language: English Journal: AIDS Rev Journal subject: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Year: 2022 Document Type: Article Affiliation country: AIDSRev.22000001