Outcome of SARS-CoV-2-Infected Polish Patients with Chronic Lymphocytic Leukemia.
Cancers (Basel)
; 14(3)2022 Jan 22.
Article
in English
| MEDLINE | ID: covidwho-1650105
ABSTRACT
BACKGROUND:
The severe acute respiratory syndrome coronavirus (SARS-CoV-2) has become the cause of a worldwide pandemic, and its clinical infection course in patients with hematological malignancies may be severe.METHODS:
We performed a retrospective study on 188 chronic lymphocytic leukemia patients (CLL) with COVID-19 infection.RESULTS:
At the time of infection 51 patients (27.1%) were treated with Bruton tyrosine kinase inhibitor (BTKi), 46 (24.5%) with anti-CD20 antibodies while 37 patients (19.7%) received venetoclax. In total, 111 patients (59.0%) required hospitalization and 50 patients (26.5%) died due to COVID-19. Patients with poor performance status (ECOG >1; p = 0.02), advanced age (>65 years; p = 0.04), low hemoglobin concentration (≤10 g/dl; p = 0.0001), low platelets (<100 × 109/L; p = 0.003), and elevated lactate dehydrogenase level (LDH; p = 0.014) had an increased risk of death due to COVID-19. Neither CLL treatment status (treatment naïve vs. treated) nor the type of CLL-directed treatment had impact on the SARS-CoV-2 related risk of death. The multivariate survival analysis showed that advanced age (p = 0.009) and low platelet count (p = 0.0001) were associated with significantly shorter patients' overall survival.CONCLUSIONS:
SARS-CoV-2 infection in CLL patients is associated with poor outcome regardless of administered CLL-directed treatment.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Observational study
/
Prognostic study
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Cancers14030558
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