Review Article: Postmortem Liver Pathology Findings in Patients With COVID-19: A Systematic Review
International Journal of Medical Toxicology and Forensic Medicine
; 11(4), 2021.
Article
in English
| EMBASE | ID: covidwho-1650587
ABSTRACT
Background:
The Coronavirus Disease 2019 (COVID-19) pandemic promptly became a significant public health challenge with extra-pulmonary manifestations, including liver damage. Postmortem examination is crucial for gaining a better understanding of these manifestations and improving patient management. This study summarized the current knowledge of the postmortem liver pathology of patients with COVID-19.Methods:
This review was conducted on studies evaluating the postmortem macroscopic and microscopic findings of the liver in patients with COVID-19. Accordingly, we searched 4 electronic databases (PubMed, Scopus, Google Scholar, & Web of Science) until June 2021. From the 317 screened articles, 16 articles examining a total of 332 patients who had died due to COVID-19 were selected.Results:
The significant findings of the liver were moderate macro and microvesicular steatosis with mild sinusoidal dilation, active lobular and portal vein thrombosis, mildly-increased lymphocyte filtration in sinusoidal space, and multifocal hepatic necrosis. Additionally, the most common comorbidities were hypertension and other metabolic diseases. In conclusion, liver damage due to COVID-19 infection has various manifestations in patients who have expired due to COVID-19.Conclusion:
Therefore, monitoring liver function during the course and treatment of this disease is necessary for better patient management and to decrease the COVID-19-induced mortality rate COVID.
adult; article; comorbidity; coronavirus, disease, 2019; female; filtration; human; human, cell; human, tissue; hypertension; liver, disease; liver, function; liver, injury; liver, necrosis; lymphocyte; male; Medline; metabolic, disorder; microvesicular, steatosis; mortality, rate; patient, care; portal, vein, thrombosis; Scopus; search, engine; systematic, review; Web, of, Science
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Reviews
/
Systematic review/Meta Analysis
Language:
English
Journal:
International Journal of Medical Toxicology and Forensic Medicine
Year:
2021
Document Type:
Article
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