Your browser doesn't support javascript.
Secondary Immunodeficiency Related to Kidney Disease (SIDKD)-Definition, Unmet Need, and Mechanisms.
Steiger, Stefanie; Rossaint, Jan; Zarbock, Alexander; Anders, Hans-Joachim.
  • Steiger S; Division of Nephrology, Department of Medicine IV, Ludwig Maximilians University Hospital of Munich, Munich, Germany.
  • Rossaint J; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.
  • Zarbock A; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.
  • Anders HJ; Division of Nephrology, Department of Medicine IV, Ludwig Maximilians University Hospital of Munich, Munich, Germany hjanders@med.uni-muenchen.de.
J Am Soc Nephrol ; 33(2): 259-278, 2022 02.
Article in English | MEDLINE | ID: covidwho-1650730
ABSTRACT
Kidney disease is a known risk factor for poor outcomes of COVID-19 and many other serious infections. Conversely, infection is the second most common cause of death in patients with kidney disease. However, little is known about the underlying secondary immunodeficiency related to kidney disease (SIDKD). In contrast to cardiovascular disease related to kidney disease, which has triggered countless epidemiologic, clinical, and experimental research activities or interventional trials, investments in tracing, understanding, and therapeutically targeting SIDKD have been sparse. As a call for more awareness of SIDKD as an imminent unmet medical need that requires rigorous research activities at all levels, we review the epidemiology of SIDKD and the numerous aspects of the abnormal immunophenotype of patients with kidney disease. We propose a definition of SIDKD and discuss the pathogenic mechanisms of SIDKD known thus far, including more recent insights into the unexpected immunoregulatory roles of elevated levels of FGF23 and hyperuricemia and shifts in the secretome of the intestinal microbiota in kidney disease. As an ultimate goal, we should aim to develop therapeutics that can reduce mortality due to infections in patients with kidney disease by normalizing host defense to pathogens and immune responses to vaccines.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Renal Insufficiency, Chronic / COVID-19 / Immunologic Deficiency Syndromes Type of study: Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: J Am Soc Nephrol Journal subject: Nephrology Year: 2022 Document Type: Article Affiliation country: Asn.2021091257

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Renal Insufficiency, Chronic / COVID-19 / Immunologic Deficiency Syndromes Type of study: Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: J Am Soc Nephrol Journal subject: Nephrology Year: 2022 Document Type: Article Affiliation country: Asn.2021091257