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Sex-dependent differences in stress-induced depression in Wistar rats are accompanied predominantly by changes in phosphatidylcholines and sphingomyelins.
Leskanicova, A; Babincak, M; Mochnacky, F; Pipova Kokosova, N; Kukelova, D; Urbanska, N; Kolesarova, M; Macekova, D; Kostolny, J; Kiskova, T.
  • Leskanicova A; University of Pavol Jozef Safarik in Kosice, Faculty of Sciences, Institute of Biology and Ecology, Kosice, Slovak Republic.
  • Babincak M; University of Pavol Jozef Safarik in Kosice, Faculty of Sciences, Institute of Biology and Ecology, Kosice, Slovak Republic.
  • Mochnacky F; University of Pavol Jozef Safarik in Kosice, Faculty of Sciences, Institute of Biology and Ecology, Kosice, Slovak Republic.
  • Pipova Kokosova N; University of Pavol Jozef Safarik in Kosice, Faculty of Sciences, Institute of Biology and Ecology, Kosice, Slovak Republic.
  • Kukelova D; University of Zurich, Department of Psychiatry, Psychotherapy and Psychosomatics, Preclinical Laboratory for Translational Research into Affective Disorders, Zurich, Switzerland.
  • Urbanska N; Masaryk University in Brno, Faculty of Medicine, Department of Anatomy, Division of Neuroanatomy, Brno, Czech Republic.
  • Kolesarova M; University of Pavol Jozef Safarik in Kosice, Faculty of Sciences, Institute of Biology and Ecology, Kosice, Slovak Republic.
  • Macekova D; University of Zilina, Faculty of Management Sciences and Informatics, Department of Informatics, Zilina, Slovak Republic.
  • Kostolny J; University of Zilina, Faculty of Management Sciences and Informatics, Department of Informatics, Zilina, Slovak Republic.
  • Kiskova T; University of Pavol Jozef Safarik in Kosice, Faculty of Sciences, Institute of Biology and Ecology, Kosice, Slovak Republic. terezia.kiskova@gmail.com.
J Physiol Pharmacol ; 72(4)2021 08.
Article in English | MEDLINE | ID: covidwho-1650772
ABSTRACT
With a high annual and lifetime prevalence, depression is becoming the leading contributor to the global disease burden. During the COVID-19 crisis, the depression and mood disorders accelerated significantly. Despite the growing evidence, the precise underlying mechanisms of depression disorders (DD) remain unknown. When studying DD in humans, there are many uncontrollable factors such as medication history, age of the patient or living conditions. In this regard, animal models provide an essential step for examining neural circuitry or molecular and cellular pathways in a controlled environment. As far as we know, women have a consistently higher prevalence of DD than men. Thus, the aim of our study was to evaluate sex-related changes in blood metabolites in a model of stress-induced depression in Wistar rats. Pregnant females were stressed using restriction of mobility in the final week of the pregnancy three times a day for 45 minutes each, three following days. After the birth, the progeny aged 60 days was stressed repeatedly. The perturbation in overall energy metabolism as well as in lipid metabolism was found. While in males, phosphatidylcholines (the most phosphatidylcholine with acyl-alkyl residue sum C404 - PC ae C404), sphingomyelins, and acylcarnitines were changed, in females, lipid metabolism perturbation was seen with the most critical alteration in hydroxysphingomyelin with acyl residue sum C161 (SM OH C161). Our results confirm that the animal model may be used further in the research of depression. Our results may provide an essential insight into the sex-dependent pathogenesis of depression and contribute to the search for effective treatment and prevention of depression with respect to sex.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sphingomyelins / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Animals / Female / Humans / Male / Pregnancy Language: English Journal subject: Pharmacology / Physiology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sphingomyelins / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Animals / Female / Humans / Male / Pregnancy Language: English Journal subject: Pharmacology / Physiology Year: 2021 Document Type: Article