Your browser doesn't support javascript.
Spike Gene Evolution and Immune Escape Mutations in Patients with Mild or Moderate Forms of COVID-19 and Treated with Monoclonal Antibodies Therapies.
Jary, Aude; Marot, Stéphane; Faycal, Antoine; Leon, Sacha; Sayon, Sophie; Zafilaza, Karen; Ghidaoui, Emna; Quoc, Stéphanie Nguyen; Nemlaghi, Safaa; Choquet, Sylvain; Dres, Martin; Pourcher, Valérie; Calvez, Vincent; Junot, Helga; Marcelin, Anne-Geneviève; Soulié, Cathia.
  • Jary A; Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), INSERM, Sorbonne Université, 75013 Paris, France.
  • Marot S; AP-HP, Pitié-Salpêtrière, Service de Virologie, Bâtiment CERVI, 47-83 Boulevard de l'Hôpital, 75013 Paris, France.
  • Faycal A; Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), INSERM, Sorbonne Université, 75013 Paris, France.
  • Leon S; AP-HP, Pitié-Salpêtrière, Service de Virologie, Bâtiment CERVI, 47-83 Boulevard de l'Hôpital, 75013 Paris, France.
  • Sayon S; AP-HP, Hôpital Pitié-Salpêtrière, Service de Maladie Infectieuses et Tropicales, 75013 Paris, France.
  • Zafilaza K; Service de Pharmacie, AP-HP, Sorbonne Université, Hôpital Pitié-Salpêtrière, 75013 Paris, France.
  • Ghidaoui E; Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), INSERM, Sorbonne Université, 75013 Paris, France.
  • Quoc SN; AP-HP, Pitié-Salpêtrière, Service de Virologie, Bâtiment CERVI, 47-83 Boulevard de l'Hôpital, 75013 Paris, France.
  • Nemlaghi S; Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), INSERM, Sorbonne Université, 75013 Paris, France.
  • Choquet S; AP-HP, Pitié-Salpêtrière, Service de Virologie, Bâtiment CERVI, 47-83 Boulevard de l'Hôpital, 75013 Paris, France.
  • Dres M; Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), INSERM, Sorbonne Université, 75013 Paris, France.
  • Pourcher V; AP-HP, Pitié-Salpêtrière, Service de Virologie, Bâtiment CERVI, 47-83 Boulevard de l'Hôpital, 75013 Paris, France.
  • Calvez V; Service d'Hématologie Clinique, AP-HP, Sorbonne Université, Hôpital Pitié-Salpêtrière, 75013 Paris, France.
  • Junot H; Service de Médecine Intensive-Réanimation (Département "R3S"), AP-HP. Sorbonne Université, Hôpital Pitié-Salpêtrière, 75013 Paris, France.
  • Marcelin AG; Service d'Hématologie Clinique, AP-HP, Sorbonne Université, Hôpital Pitié-Salpêtrière, 75013 Paris, France.
  • Soulié C; Service de Médecine Intensive-Réanimation (Département "R3S"), AP-HP. Sorbonne Université, Hôpital Pitié-Salpêtrière, 75013 Paris, France.
Viruses ; 14(2)2022 01 24.
Article in English | MEDLINE | ID: covidwho-1650825
ABSTRACT
We explored the molecular evolution of the spike gene after the administration of anti-spike monoclonal antibodies in patients with mild or moderate forms of COVID-19. Four out of the 13 patients acquired a mutation during follow-up; two mutations (G1204E and E406G) appeared as a mixture without clinical impact, while the Q493R mutation emerged in two patients (one receiving bamlanivimab and one receiving bamlanivimab/etesevimab) with fatal outcomes. Careful virological monitoring of patients treated with mAbs should be performed, especially in immunosuppressed patients.
Subject(s)
Keywords
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Evolution, Molecular / Immune Evasion / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 / Antibodies, Monoclonal / Mutation Type of study: Cohort study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Year: 2022 Document Type: Article Affiliation country: V14020226

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Evolution, Molecular / Immune Evasion / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 / Antibodies, Monoclonal / Mutation Type of study: Cohort study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Year: 2022 Document Type: Article Affiliation country: V14020226