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Type I interferons and SARS-CoV-2: from cells to organisms.
Bastard, Paul; Zhang, Qian; Zhang, Shen-Ying; Jouanguy, Emmanuelle; Casanova, Jean-Laurent.
  • Bastard P; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France; University of Paris, Imagine Institute, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, Ne
  • Zhang Q; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France; University of Paris, Imagine Institute, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, Ne
  • Zhang SY; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France; University of Paris, Imagine Institute, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, Ne
  • Jouanguy E; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France; University of Paris, Imagine Institute, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, Ne
  • Casanova JL; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France; University of Paris, Imagine Institute, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, Ne
Curr Opin Immunol ; 74: 172-182, 2022 02.
Article in English | MEDLINE | ID: covidwho-1650997
ABSTRACT
Type I interferons (IFNs) have broad and potent antiviral activity. We review the interplay between type I IFNs and SARS-CoV-2. Human cells infected with SARS-CoV-2 in vitro produce low levels of type I IFNs, and SARS-CoV-2 proteins can inhibit various steps in type I IFN production and response. Exogenous type I IFNs inhibit viral growth in vitro. In various animal species infected in vivo, type I IFN deficiencies underlie higher viral loads and more severe disease than in control animals. The early administration of exogenous type I IFNs improves infection control. In humans, inborn errors of, and auto-antibodies against type I IFNs underlie life-threatening COVID-19 pneumonia. Overall, type I IFNs are essential for host defense against SARS-CoV-2 in individual cells and whole organisms.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferon Type I / SARS-CoV-2 / COVID-19 Limits: Animals / Humans Language: English Journal: Curr Opin Immunol Journal subject: Allergy and Immunology Year: 2022 Document Type: Article Affiliation country: J.coi.2022.01.003

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferon Type I / SARS-CoV-2 / COVID-19 Limits: Animals / Humans Language: English Journal: Curr Opin Immunol Journal subject: Allergy and Immunology Year: 2022 Document Type: Article Affiliation country: J.coi.2022.01.003