Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19
Organic process research & development
; 25(12):2806-2815, 2021.
Article
in English
| EuropePMC | ID: covidwho-1651894
ABSTRACT
Herein is described the development of a large-scale manufacturing process for molnupiravir, an orally dosed antiviral that was recently demonstrated to be efficacious for the treatment of patients with COVID-19. The yield, robustness, and efficiency of each of the five steps were improved, ultimately culminating in a 1.6-fold improvement in overall yield and a dramatic increase in the overall throughput compared to the baseline process.
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Collection:
Databases of international organizations
Database:
EuropePMC
Language:
English
Journal:
Organic process research & development
Year:
2021
Document Type:
Article
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