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Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants.
Park, Junsoo; Park, Rackhyun; Jang, Minsu; Park, Yea-In; Park, Yeonjeong.
  • Park J; Division of Biological Science and Technology, Yonsei University, Wonju, 26493, Republic of Korea. junsoo@yonsei.ac.kr.
  • Park R; Division of Biological Science and Technology, Yonsei University, Wonju, 26493, Republic of Korea.
  • Jang M; Division of Biological Science and Technology, Yonsei University, Wonju, 26493, Republic of Korea.
  • Park YI; Division of Biological Science and Technology, Yonsei University, Wonju, 26493, Republic of Korea.
  • Park Y; Division of Biological Science and Technology, Yonsei University, Wonju, 26493, Republic of Korea.
J Microbiol ; 60(3): 347-354, 2022 Mar.
Article in English | MEDLINE | ID: covidwho-1652455
ABSTRACT
Coronavirus disease (COVID-19) can cause critical conditions that require efficient therapeutics. Several medicines are derived from plants, and researchers are seeking natural compounds to ameliorate the symptoms of COVID-19. Viral enzymes are popular targets of antiviral medicines; the genome of coronaviruses encodes several enzymes, including RNA-dependent RNA polymerase and viral proteases. Various screening systems have been developed to identify potential inhibitors. In this review, we describe the natural compounds that have been shown to exert inhibitory effects on coronavirus enzymes. Although computer-aided molecular structural studies have predicted several antiviral compound candidates, the current review focuses on experimentally proven natural compounds.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Enzyme Inhibitors / Phytochemicals / COVID-19 Limits: Humans Language: English Journal: J Microbiol Journal subject: Microbiology Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Enzyme Inhibitors / Phytochemicals / COVID-19 Limits: Humans Language: English Journal: J Microbiol Journal subject: Microbiology Year: 2022 Document Type: Article