Your browser doesn't support javascript.
Limited spread of a rare spike E484K-harboring SARS-CoV-2 in Marseille, France.
Colson, Philippe; Fantini, Jacques; Yahi, Nouara; Delerce, Jeremy; Levasseur, Anthony; Fournier, Pierre-Edouard; Lagier, Jean-Christophe; Raoult, Didier; La Scola, Bernard.
  • Colson P; IHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13005, Marseille, France. philippe.colson@univ-amu.fr.
  • Fantini J; Aix-Marseille Univ., Institut de Recherche pour le Développement (IRD), Assistance Publique-Hôpitaux de Marseille (AP-HM), MEPHI, 27 boulevard Jean Moulin, 13005, Marseille, France. philippe.colson@univ-amu.fr.
  • Yahi N; Aix-Marseille Univ., INSERM U_1072, 13015, Marseille, France.
  • Delerce J; Aix-Marseille Univ., INSERM U_1072, 13015, Marseille, France.
  • Levasseur A; IHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13005, Marseille, France.
  • Fournier PE; IHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13005, Marseille, France.
  • Lagier JC; Aix-Marseille Univ., Institut de Recherche pour le Développement (IRD), Assistance Publique-Hôpitaux de Marseille (AP-HM), MEPHI, 27 boulevard Jean Moulin, 13005, Marseille, France.
  • Raoult D; IHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13005, Marseille, France.
  • La Scola B; Aix-Marseille Univ., Institut de Recherche pour le Développement (IRD), Assistance Publique-Hôpitaux de Marseille (AP-HM), MEPHI, 27 boulevard Jean Moulin, 13005, Marseille, France.
Arch Virol ; 167(2): 583-589, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1653517
ABSTRACT
We detected SARS-CoV-2 of PANGO lineage R.1 with the spike substitution E484K in three patients. Eleven other sequences in France and 8,831 worldwide were available from GISAID, 92% originating from Japan. The three genome sequences from our institute were phylogenetically closest to another from Guinea-Conakry, where one of the patients had travelled. These viruses did not exhibit any unusual features in cell culture. Spike structural predictions indicated a 1.3-time higher transmissibility index than for the globally spread B.1.1.7 variant but also an affinity loss for gangliosides that might have slowed dissemination. The spread of new SARS-CoV-2 mutants/variants is still not well understood and therefore difficult to predict, and this hinders implementation of effective preventive measures, including adapted vaccines.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Vaccines / Variants Limits: Humans Country/Region as subject: Africa Language: English Journal: Arch Virol Year: 2022 Document Type: Article Affiliation country: S00705-021-05331-4

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Vaccines / Variants Limits: Humans Country/Region as subject: Africa Language: English Journal: Arch Virol Year: 2022 Document Type: Article Affiliation country: S00705-021-05331-4