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Risk factors for COVID-19-related death, hospitalization and intensive care: a population-wide study of all inhabitants in Stockholm.
Hergens, Maria-Pia; Bell, Max; Haglund, Per; Sundström, Johan; Lampa, Erik; Nederby-Öhd, Joanna; Östlund, Maria Rotzén; Cars, Thomas.
  • Hergens MP; Department of Medicine Karolinska Solna, Unit of Infectious Diseases, Karolinska Institutet, Stockholm, Sweden. maria-pia.hergens@regionstockholm.se.
  • Bell M; Department of Communicable Disease Control and Prevention, Stockholm Region, Sweden. maria-pia.hergens@regionstockholm.se.
  • Haglund P; Section of Anaesthesiology and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
  • Sundström J; Department of Perioperative Medicine and Intensive Care (PMI), Karolinska University Hospital, Solna, Stockholm, Sweden.
  • Lampa E; Department of Health Care Analysis and Statistics, Public Healthcare Services Committee, Stockholm Region, Sweden.
  • Nederby-Öhd J; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
  • Östlund MR; The George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia.
  • Cars T; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Eur J Epidemiol ; 37(2): 157-165, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1653597
ABSTRACT
Since the beginning of the Covid-19 pandemic, the scientific community has explored determinants of Covid 19 disease severity. However, the majority of studies are based on in-hospital patients with high risk of collider- or selection bias. The present investigation details risk factors associated with overall mortality, hospitalization and intensive care unit (ICU) admission in Covid-19 infections, with complete population coverage and high-resolution data on patient characteristics and comorbid conditions This population-based observational study comprises all residents 18 years and older in Stockholm Region-1.8 million inhabitants-using the real-time Covid-19 monitoring framework. The observation period lasted between March 1 to December 31, 2020. Hazard ratios (HR) for risk factors of Covid-19 disease severity were assessed using Cox proportional hazard models. In total, 3322 deaths, 11,508 hospitalizations and 1423 ICU-admissions related to Covid-19 occurred during the study period. Kidney failure, diabetes and obesity increased risk of mortality and so did heart failure and ischemic heart disease. However, atrial fibrillation and hypertension did not. Risk of hospitalization follow a similar pattern, whereas admission to intensive care differs; triage processes where clearly present as certain co-morbid conditions were associated with lower ICU admission. Observed differences in risk of mortality and hospitalization among patients with Covid 19 raise important questions about potentially protective comedication which will be further addressed using the real-time Covid-19 monitoring framework.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Eur J Epidemiol Journal subject: Epidemiology Year: 2022 Document Type: Article Affiliation country: S10654-021-00840-7

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Eur J Epidemiol Journal subject: Epidemiology Year: 2022 Document Type: Article Affiliation country: S10654-021-00840-7