Coordinated regulation of interferon and inflammasome signaling pathways by SARS-CoV-2 proteins.
J Microbiol
; 60(3): 300-307, 2022 Mar.
Article
in English
| MEDLINE | ID: covidwho-1653793
ABSTRACT
Type I and III interferons (IFNs) and the nucleotide-binding domain (NBD) leucine-rich repeat (LRR)-containing receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome play pivotal roles in the pathogenesis of SARS-CoV-2. While optimal IFN and inflammasome responses are essential for limiting SARS-CoV-2 infection, aberrant activation of these innate immune responses is associated with COVID-19 pathogenesis. In this review, we focus our discussion on recent findings on SARS-CoV-2-induced type I and III IFNs and NLRP3 inflammasome responses and the viral proteins regulating these mechanisms.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Interferons
/
Inflammasomes
/
NLR Family, Pyrin Domain-Containing 3 Protein
/
COVID-19
Limits:
Humans
Language:
English
Journal:
J Microbiol
Journal subject:
Microbiology
Year:
2022
Document Type:
Article
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