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Effectiveness of Disinfectants Suitable for Inactivating SARS-CoV-2 at Cold-Chain Temperature.
Wu, Xiaosong; Chen, Yin; Wang, Ling; Guo, Xiling; Cui, Lunbiao; Shen, Yiming; Li, Fang; Sun, Hong; Zhang, Liubo; Shen, Jin; Xu, Yan.
  • Wu X; Jiangsu Provincial Center for Disease Control and Prevention, 172 Jiangsu Road, Nanjing, 210009, Jiangsu, China.
  • Chen Y; National Health Committee Key Laboratory of Enteric Pathogenic Microbiology, 172 Jiangsu Road, Nanjing, 210009, China.
  • Wang L; Jiangsu Provincial Center for Disease Control and Prevention, 172 Jiangsu Road, Nanjing, 210009, Jiangsu, China.
  • Guo X; National Health Committee Key Laboratory of Enteric Pathogenic Microbiology, 172 Jiangsu Road, Nanjing, 210009, China.
  • Cui L; Jiangsu Provincial Center for Disease Control and Prevention, 172 Jiangsu Road, Nanjing, 210009, Jiangsu, China.
  • Shen Y; Jiangsu Provincial Center for Disease Control and Prevention, 172 Jiangsu Road, Nanjing, 210009, Jiangsu, China.
  • Li F; National Health Committee Key Laboratory of Enteric Pathogenic Microbiology, 172 Jiangsu Road, Nanjing, 210009, China.
  • Sun H; Jiangsu Provincial Center for Disease Control and Prevention, 172 Jiangsu Road, Nanjing, 210009, Jiangsu, China.
  • Zhang L; National Health Committee Key Laboratory of Enteric Pathogenic Microbiology, 172 Jiangsu Road, Nanjing, 210009, China.
  • Shen J; Jiangsu Provincial Center for Disease Control and Prevention, 172 Jiangsu Road, Nanjing, 210009, Jiangsu, China.
  • Xu Y; Jiangsu Provincial Center for Disease Control and Prevention, 172 Jiangsu Road, Nanjing, 210009, Jiangsu, China.
Food Environ Virol ; 14(1): 101-104, 2022 03.
Article in English | MEDLINE | ID: covidwho-1653805
ABSTRACT
To prevent the spread of SARS-CoV-2 in cold-chain transportation in China, we developed specific cryogenic disinfectants. Carrier tests were performed against SARS-CoV-2 at - 20 °C for the four cryogenic disinfectants developed and qRT-PCR was used to test the virus RNA. Peracetic acid, chlorine disinfectants (two different concentrations), and quaternary ammonium disinfectant with their antifreeze can all inactivate SARS-CoV-2 in 5 min at - 20 °C. However, after 2-3 h of exposure, only chlorine disinfectant could destroy SARS-CoV-2 RNA. The viruses treated with peracetic acid and quaternary disinfectants showed positive Ct values even after 3 h detected with qRT-PCR. The conclusion was that the cold-chain disinfectants we tested could inactivate SARS-CoV-2 quickly and effectively, but only chlorine disinfectants could destroy nucleic acids in 3 h. Our study also illustrated that using qRT-PCR detection of viral nucleic acids to assess disinfection was inappropriate.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Disinfectants / COVID-19 Type of study: Experimental Studies Limits: Humans Language: English Journal: Food Environ Virol Year: 2022 Document Type: Article Affiliation country: S12560-022-09509-0

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Disinfectants / COVID-19 Type of study: Experimental Studies Limits: Humans Language: English Journal: Food Environ Virol Year: 2022 Document Type: Article Affiliation country: S12560-022-09509-0