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Brain correlates of depression, post-traumatic distress, and inflammatory biomarkers in COVID-19 survivors: A multimodal magnetic resonance imaging study.
Benedetti, Francesco; Palladini, Mariagrazia; Paolini, Marco; Melloni, Elisa; Vai, Benedetta; De Lorenzo, Rebecca; Furlan, Roberto; Rovere-Querini, Patrizia; Falini, Andrea; Mazza, Mario Gennaro.
  • Benedetti F; Vita-Salute San Raffaele University, Milano, Italy.
  • Palladini M; Psychiatry & Clinical Psychobiology, Division of Neuroscience, IRCCS Scientific Institute Ospedale San Raffaele, Milano, Italy.
  • Paolini M; Psychiatry & Clinical Psychobiology, Division of Neuroscience, IRCCS Scientific Institute Ospedale San Raffaele, Milano, Italy.
  • Melloni E; Vita-Salute San Raffaele University, Milano, Italy.
  • Vai B; Psychiatry & Clinical Psychobiology, Division of Neuroscience, IRCCS Scientific Institute Ospedale San Raffaele, Milano, Italy.
  • De Lorenzo R; PhD Program in Molecular Medicine, University Vita-Salute San Raffaele, Milan, Italy.
  • Furlan R; Vita-Salute San Raffaele University, Milano, Italy.
  • Rovere-Querini P; Psychiatry & Clinical Psychobiology, Division of Neuroscience, IRCCS Scientific Institute Ospedale San Raffaele, Milano, Italy.
  • Falini A; Vita-Salute San Raffaele University, Milano, Italy.
  • Mazza MG; Psychiatry & Clinical Psychobiology, Division of Neuroscience, IRCCS Scientific Institute Ospedale San Raffaele, Milano, Italy.
Brain Behav Immun Health ; 18: 100387, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1654092
ABSTRACT
Psychiatric sequelae substantially contribute to the post-acute burden of disease associated with COVID-19, persisting months after clearance of the virus. Brain imaging shows white matter (WM) hypodensities/hyperintensities, and the involvement of grey matter (GM) in prefrontal, anterior cingulate (ACC) and insular cortex after COVID, but little is known about brain correlates of persistent psychopathology. With a multimodal approach, we studied whole brain voxel-based morphometry, diffusion-tensor imaging, and resting-state connectivity, to correlate MRI measures with depression and post-traumatic distress (PTSD) in 42 COVID-19 survivors without brain lesions, at 90.59 â€‹± â€‹54.66 days after COVID. Systemic immune-inflammation index (SII) measured in the emergency department, which reflects the immune response and systemic inflammation based on peripheral lymphocyte, neutrophil, and platelet counts, predicted worse self-rated depression and PTSD, widespread lower diffusivity along the main axis of WM tracts, and abnormal functional connectivity (FC) among resting state networks. Self-rated depression and PTSD inversely correlated with GM volumes in ACC and insula, axial diffusivity, and associated with FC. We observed overlapping associations between severity of inflammation during acute COVID-19, brain structure and function, and severity of depression and post-traumatic distress in survivors, thus warranting interest for further study of brain correlates of the post-acute COVID-19 syndrome. Beyond COVID-19, these findings support the hypothesis that regional GM, WM microstructure, and FC could mediate the relationship between a medical illness and its psychopathological sequelae, and are in agreement with current perspectives on the brain structural and functional underpinnings of depressive psychopathology.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Long Covid Language: English Journal: Brain Behav Immun Health Year: 2021 Document Type: Article Affiliation country: J.bbih.2021.100387

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Long Covid Language: English Journal: Brain Behav Immun Health Year: 2021 Document Type: Article Affiliation country: J.bbih.2021.100387