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SARS-CoV-2 can induce brain and spine demyelinating lesions.
Zanin, Luca; Saraceno, Giorgio; Panciani, Pier Paolo; Renisi, Giulia; Signorini, Liana; Migliorati, Karol; Fontanella, Marco Maria.
  • Zanin L; Neurosurgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Spedali Civili di Brescia, Piazzale Spedali Civili, 1, 25124, Brescia, Italy.
  • Saraceno G; Neurosurgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Spedali Civili di Brescia, Piazzale Spedali Civili, 1, 25124, Brescia, Italy.
  • Panciani PP; Neurosurgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Spedali Civili di Brescia, Piazzale Spedali Civili, 1, 25124, Brescia, Italy. pierpaolo.panciani@gmail.com.
  • Renisi G; Department of Infection and Tropical Disease, University of Brescia, Brescia, Italy.
  • Signorini L; Department of Infection and Tropical Disease, University of Brescia, Brescia, Italy.
  • Migliorati K; Neurosurgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Spedali Civili di Brescia, Piazzale Spedali Civili, 1, 25124, Brescia, Italy.
  • Fontanella MM; Neurosurgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Spedali Civili di Brescia, Piazzale Spedali Civili, 1, 25124, Brescia, Italy.
Acta Neurochir (Wien) ; 162(7): 1491-1494, 2020 Jul.
Article in English | MEDLINE | ID: covidwho-165424
ABSTRACT
SARS-CoV-2 can attack the central nervous system in the early stages of infection. Headache, anosmia, and dysgeusia are common symptoms. Disturbance of consciousness and seizures can occur as complications in case of severe COVID-19. We described the case of a COVID-19 patient admitted for interstitial pneumonia and seizures. MRI showed newly diagnosed demyelinating lesions. High-dose steroid treatment allowed neurological and respiratory recovery. We speculated a delayed immune response induced by SARS-CoV-2. The virus may lead to a SIRS-like immune disorder or play a role of infective trigger. Prompt invasive treatment should be adopted to avoid hypoxic neurotoxicity and prevent CNS injuries.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Acta Neurochir (Wien) Year: 2020 Document Type: Article Affiliation country: S00701-020-04374-x

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Acta Neurochir (Wien) Year: 2020 Document Type: Article Affiliation country: S00701-020-04374-x