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Efficacy and self-similarity of SARS-CoV-2 thermal decontamination.
Yap, Te Faye; Hsu, Jason C; Liu, Zhen; Rayavara, Kempaiah; Tat, Vivian; Tseng, Chien-Te K; Preston, Daniel J.
  • Yap TF; Department of Mechanical Engineering, George R. Brown School of Engineering, Rice University, 6100 Main St., Houston, TX 77005, USA.
  • Hsu JC; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555, USA.
  • Liu Z; Department of Mechanical Engineering, George R. Brown School of Engineering, Rice University, 6100 Main St., Houston, TX 77005, USA.
  • Rayavara K; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555, USA.
  • Tat V; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555, USA.
  • Tseng CK; Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555, USA; Center for Biodefense and Emerging Diseases, Galveston National Laboratory, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555, USA.
  • Preston DJ; Department of Mechanical Engineering, George R. Brown School of Engineering, Rice University, 6100 Main St., Houston, TX 77005, USA. Electronic address: djp@rice.edu.
J Hazard Mater ; 429: 127709, 2022 05 05.
Article in English | MEDLINE | ID: covidwho-1654743
ABSTRACT
Dry heat decontamination has been shown to effectively inactivate viruses without compromising the integrity of delicate personal protective equipment (PPE), allowing safe reuse and helping to alleviate shortages of PPE that have arisen due to COVID-19. Unfortunately, current thermal decontamination guidelines rely on empirical data which are often sparse, limited to a specific virus, and unable to provide fundamental insight into the underlying inactivation reaction. In this work, we experimentally quantified dry heat decontamination of SARS-CoV-2 on disposable masks and validated a model that treats the inactivation reaction as thermal degradation of macromolecules. Furthermore, upon nondimensionalization, all of the experimental data collapse onto a unified curve, revealing that the thermally driven decontamination process exhibits self-similar behavior. Our results show that heating surgical masks to 70 °C for 5 min inactivates over 99.9% of SARS-CoV-2. We also characterized the chemical and physical properties of disposable masks after heat treatment and did not observe degradation. The model presented in this work enables extrapolation of results beyond specific temperatures to provide guidelines for safe PPE decontamination. The modeling framework and self-similar behavior are expected to extend to most viruses-including yet-unencountered novel viruses-while accounting for a range of environmental conditions.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: J Hazard Mater Journal subject: Environmental Health Year: 2022 Document Type: Article Affiliation country: J.jhazmat.2021.127709

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: J Hazard Mater Journal subject: Environmental Health Year: 2022 Document Type: Article Affiliation country: J.jhazmat.2021.127709