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Sickle cell disease and COVID-19 in pregnant women.
Kolanska, Kamila; Vasileva, Radostina; Lionnet, François; Santin, Aline; Jaudi, Suha; Dabi, Yohann; Chabbert-Buffet, Nathalie; Daraï, Emile; Bornes, Marie.
  • Kolanska K; Department of Gynecology Obstetrics and Reproductive Medicine, Tenon Hospital, AP-HP, Sorbonne University, 4 rue de la Chine, Paris 75020, France. Electronic address: kamila.kolanska@aphp.fr.
  • Vasileva R; Department of Gynecology Obstetrics and Reproductive Medicine, Tenon Hospital, AP-HP, Sorbonne University, 4 rue de la Chine, Paris 75020, France.
  • Lionnet F; Department of Internal Medicine, Reference Center of Sickle cell Anemia (AP-HP), University Hospital Center of Tenon, Sorbonne University, rue de la Chine, Paris 75020, France.
  • Santin A; Department of Internal Medicine, Reference Center of Sickle cell Anemia (AP-HP), University Hospital Center of Tenon, Sorbonne University, rue de la Chine, Paris 75020, France.
  • Jaudi S; Department of Gynecology Obstetrics and Reproductive Medicine, Tenon Hospital, AP-HP, Sorbonne University, 4 rue de la Chine, Paris 75020, France.
  • Dabi Y; Department of Gynecology Obstetrics and Reproductive Medicine, Tenon Hospital, AP-HP, Sorbonne University, 4 rue de la Chine, Paris 75020, France.
  • Chabbert-Buffet N; Department of Gynecology Obstetrics and Reproductive Medicine, Tenon Hospital, AP-HP, Sorbonne University, 4 rue de la Chine, Paris 75020, France.
  • Daraï E; Department of Gynecology Obstetrics and Reproductive Medicine, Tenon Hospital, AP-HP, Sorbonne University, 4 rue de la Chine, Paris 75020, France.
  • Bornes M; Department of Gynecology Obstetrics and Reproductive Medicine, Tenon Hospital, AP-HP, Sorbonne University, 4 rue de la Chine, Paris 75020, France.
J Gynecol Obstet Hum Reprod ; 51(3): 102328, 2022 Mar.
Article in English | MEDLINE | ID: covidwho-1654804
ABSTRACT

INTRODUCTION:

The effect of coronavirus disease (COVID-19) on pregnancy outcome in women with sickle cell disease (SCD) is unknown.

OBJECTIVES:

To analyze the severity of the SARS-CoV-2 infection in pregnant women with SCD and its impact on pregnancy.

METHODS:

This retrospective cohort study included SCD pregnant women tested positive for COVID-19 between March 2020 - February 2021. The primary endpoint was the severity of the COVID-19 infection. Secondary endpoints were pregnancy complications and fetal outcomes.

RESULTS:

During the study period among 82 pregnant women with SCD, 8 have presented symptoms suggestive of COVID-19 and were tested positive. A common mild clinical presentation was observed in 6 women (75%), one woman was asymptomatic and one required oxygen. The latter was admitted to the Intensive Care Unit and a cesarean section was performed in the context of an ongoing vaso-occlusive crisis and acute chest syndrome together with incidental preeclampsia. Labor was induced in another patient who developed a vaso-occlusive crisis after COVID-19 remission. Fetal outcomes were good with an average Apgar score of 10 and normal umbilical blood pH at birth. Two newborns were small-for-gestational-age as expected on the ultrasound follow-up before occurrence of COVID-19.

CONCLUSION:

COVID-19 infection in our population of pregnant women with SCD had typical presentation and rarely triggered a sickle cell crisis or other complications. Fetal outcomes were good and did not seem to be directly influenced by the SARS-CoV-2 virus. Further studies are required to confirm these observations as compared to the population of women with SCD without COVID-19 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / COVID-19 / Anemia, Sickle Cell Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: J Gynecol Obstet Hum Reprod Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / COVID-19 / Anemia, Sickle Cell Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: J Gynecol Obstet Hum Reprod Year: 2022 Document Type: Article