Mendelian randomization study of obesity and type 2 diabetes in hospitalized COVID-19 patients.
Metabolism
; 129: 155156, 2022 04.
Article
in English
| MEDLINE | ID: covidwho-1654927
ABSTRACT
BACKGROUND:
Both obesity and type 2 diabetes (T2D) are reported to be highly enriched in hospitalized COVID-19 patients. Due to the close correlation between obesity and T2D, it is important to examine whether obesity and T2D are independently related to COVID-19 hospitalization.OBJECTIVE:
To examine the causal effect of obesity and T2D in hospitalized COVID-19 patients using Mendelian randomization (MR). RESEARCH DESIGN ANDMETHODS:
This two-sample MR analysis applied genetic markers of obesity identified in the genome wide association study (GWAS) by the GIANT Consortium as instrumental variables (IVs) of obesity; and genetic markers of T2D identified by the DIAGRAM Consortium as IVs of T2D. The MR analysis was performed in hospitalized COVID-19 patient by the COVID-19 Host Genetics Initiative using the MR-Base platform.RESULTS:
All 3 classes of obesity (Class 1/2/3) were shown as the causal risk factors of COVID-19 hospitalization; however, T2D doesn't increase the risk of hospitalization or critically ill COVID-19 as an independent factor.CONCLUSIONS:
Obesity, but not T2D, is a primary risk factor of COVID-19 hospitalization.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Diabetes Mellitus, Type 2
/
Mendelian Randomization Analysis
/
SARS-CoV-2
/
COVID-19
/
Hospitalization
/
Obesity
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Metabolism
Year:
2022
Document Type:
Article
Affiliation country:
J.metabol.2022.155156
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