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Laser induced breakdown spectroscopy for the rapid detection of SARS-CoV-2 immune response in plasma.
Berlo, K; Xia, W; Zwillich, F; Gibbons, E; Gaudiuso, R; Ewusi-Annan, E; Chiklis, G R; Melikechi, N.
  • Berlo K; Department of Earth and Planetary Sciences, GEOTOP Research Centre, McGill University, Montreal, Canada. kim.berlo@mcgill.ca.
  • Xia W; Geriatric Research Education Clinical Center, Bedford VA Healthcare System, Bedford, MA, USA.
  • Zwillich F; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
  • Gibbons E; Department of Earth and Planetary Sciences, GEOTOP Research Centre, McGill University, Montreal, Canada.
  • Gaudiuso R; Department of Earth and Planetary Sciences, GEOTOP Research Centre, McGill University, Montreal, Canada.
  • Ewusi-Annan E; Department of Physics and Applied Physics, Kennedy College of Sciences, University of Massachusetts Lowell, Lowell, MA, USA.
  • Chiklis GR; Department of Physics and Applied Physics, Kennedy College of Sciences, University of Massachusetts Lowell, Lowell, MA, USA.
  • Melikechi N; MRN Diagnostics, Franklin, MA, USA.
Sci Rep ; 12(1): 1614, 2022 01 31.
Article in English | MEDLINE | ID: covidwho-1661979
ABSTRACT
As the SARS-CoV-2 pandemic persists, methods that can quickly and reliably confirm infection and immune status is extremely urgently and critically needed. In this contribution we show that combining laser induced breakdown spectroscopy (LIBS) with machine learning can distinguish plasma of donors who previously tested positive for SARS-CoV-2 by RT-PCR from those who did not, with up to 95% accuracy. The samples were also analyzed by LIBS-ICP-MS in tandem mode, implicating a depletion of Zn and Ba in samples of SARS-CoV-2 positive subjects that inversely correlate with CN lines in the LIBS spectra.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Spectrophotometry, Atomic / Pandemics / SARS-CoV-2 / COVID-19 / Immunity / Lasers Type of study: Diagnostic study / Observational study Topics: Long Covid Limits: Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-05509-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Spectrophotometry, Atomic / Pandemics / SARS-CoV-2 / COVID-19 / Immunity / Lasers Type of study: Diagnostic study / Observational study Topics: Long Covid Limits: Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-05509-z