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Cannabis-related allergies: An international overview and consensus recommendations.
Skypala, Isabel J; Jeimy, Samira; Brucker, Hannelore; Nayak, Ajay P; Decuyper, Ine I; Bernstein, Jonathan A; Connors, Lori; Kanani, Amin; Klimek, Ludger; Lo, Shun Chi Ryan; Murphy, Kevin R; Nanda, Anil; Poole, Jill A; Walusiak-Skorupa, Jolanta; Sussman, Gordon; Zeiger, Joanna S; Goodman, Richard E; Ellis, Anne K; Silvers, William S; Ebo, Didier G.
  • Skypala IJ; Department of Allergy & Clinical Immunology, Royal Brompton & Harefield Hospitals, and Imperial College, London, UK.
  • Jeimy S; Division of Clinical Immunology and Allergy, Department of Medicine, Western University, London, Ontario, Canada.
  • Brucker H; Southdale Allergy and Asthma Clinic, Minneapolis, Minnesota, USA.
  • Nayak AP; Center for Translational Medicine and Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, Jane and Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
  • Decuyper II; Department of Pediatrics, Faculty of Medicine and Health Sciences, University Hospital of Antwerp, University of Antwerp, Antwerp, Belgium.
  • Bernstein JA; Division of Immunology/Allergy Section, Department of Internal Medicine, University of Cincinnati College of Medicine and Bernstein Allergy Group; Bernstein Clinical Research Center, Cincinnati, Ohio, USA.
  • Connors L; Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Kanani A; Division of Allergy and Immunology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Klimek L; Center for Rhinology and Allergy, Wiesbaden, Germany.
  • Lo SCR; Division of Allergy and Immunology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Murphy KR; Division of Allergy, Asthma and Pediatric Pulmonology, Department of Pediatrics, Boys Town National Research Hospital, Omaha, Nebraska, USA.
  • Nanda A; Asthma and Allergy Center, Lewisville and Flower Mound, Dallas, Texas, USA.
  • Poole JA; Division of Allergy and Immunology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Walusiak-Skorupa J; Division of Allergy and Immunology, Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Sussman G; Department of Occupational Medicine and Environmental Health, Nofer Institute of Occupational Medicine, Lodz, Poland.
  • Zeiger JS; Department of Medicine and Division of Clinical Immunology & Allergy, University of Toronto, Toronto, Ontario, Canada.
  • Goodman RE; Canna Research Foundation, Boulder, Colorado, USA.
  • Ellis AK; Food Allergy Research and Resource Program, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
  • Silvers WS; Division of Allergy & Immunology, Department of Medicine, Queen's University, Kingston, Ontario, Canada.
  • Ebo DG; Division of Allergy Clinical Immunology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Allergy ; 77(7): 2038-2052, 2022 07.
Article in English | MEDLINE | ID: covidwho-1662232
ABSTRACT
Cannabis is the most widely used recreational drug in the world. Cannabis sativa and Cannabis indica have been selectively bred to develop their psychoactive properties. The increasing use in many countries has been accelerated by the COVID-19 pandemic. Cannabis can provoke both type 1 and type 4 allergic reactions. Officially recognized allergens include a pathogenesis-related class 10 allergen, profilin, and a nonspecific lipid transfer protein. Other allergens may also be relevant, and recognition of allergens may vary between countries and continents. Cannabis also has the potential to provoke allergic cross-reactions to plant foods. Since cannabis is an illegal substance in many countries, research has been hampered, leading to challenges in diagnosis since no commercial extracts are available for testing. Even in countries such as Canada, where cannabis is legalized, diagnosis may rely solely on the purchase of cannabis for prick-to-prick skin tests. Management consists of avoidance, with legal issues hindering the development of other treatments such as immunotherapy. Education of healthcare professionals is similarly lacking. This review aimed to summarize the current status of cannabis allergy and proposes recommendations for the future management of this global issue.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cannabis / Food Hypersensitivity / COVID-19 / Hypersensitivity Type of study: Diagnostic study / Observational study / Randomized controlled trials Limits: Humans Language: English Journal: Allergy Year: 2022 Document Type: Article Affiliation country: All.15237

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cannabis / Food Hypersensitivity / COVID-19 / Hypersensitivity Type of study: Diagnostic study / Observational study / Randomized controlled trials Limits: Humans Language: English Journal: Allergy Year: 2022 Document Type: Article Affiliation country: All.15237