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Micronutrient Level Is Negatively Correlated with the Neutrophil-Lymphocyte Ratio in Patients with Severe COVID-19.
Zhou, Shengyu; Zhang, Fayan; Chen, Fangfang; Li, Peng; He, Yujie; Wu, Julong; Dong, Liang; Wang, Chunting; Wang, Ximing; Zhang, Wei; Sun, Wenqing; Yin, Lixia; Zhang, Rumin; Zhao, Jintong; Sun, Baoxia.
  • Zhou S; Clinical Nursing Department, School of Nursing, Cheeloo College of Medicine, Shandong University, Jinan, China.
  • Zhang F; Department of Respiratory and Critical Care Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
  • Chen F; College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
  • Li P; Health Inspection and Testing Institute, Shandong Provincial Center for Disease Control and Prevention, Jinan, China.
  • He Y; Blood Center of Shandong Province, Jinan, China.
  • Wu J; Institute of Virology, Shandong Provincial Center for Disease Control and Prevention, Jinan, China.
  • Dong L; Institute of Virology, Shandong Provincial Center for Disease Control and Prevention, Jinan, China.
  • Wang C; Department of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.
  • Wang X; The First Affiliated Hospital of Shandong First Medical University, Shandong Institute of Respiratory Diseases, Jinan, China.
  • Zhang W; Department of Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
  • Sun W; Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong University, Jinan, China.
  • Yin L; Department of Lung Disease, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
  • Zhang R; Department of Intensive Care Unit, Shandong Provincial Chest Hospital, Jinan, China.
  • Zhao J; Department of Respiratory Medicine, Dezhou People's Hospital, Dezhou, China.
  • Sun B; Department of Critical Care Medicine, Zibo Central Hospital, Zibo, China.
Int J Clin Pract ; 2022: 6498794, 2022.
Article in English | MEDLINE | ID: covidwho-1662352
ABSTRACT

Aim:

To explore the potential relationship between NLR and micronutrient deficiency in patients with severe COVID-19 infection.

Methods:

Sixteen patients were categorized into the mild group (mild COVID-19) and severe group (severe COVID-19) based on the guideline of the management of COVID-19. The lactate dehydrogenase (LDH); superoxide dismutase (SOD), the inflammatory markers (neutrophil lymphocyte ratio (NLR)), erythrocyte sedimentation rate (ESR), c-reactive protein (CRP), selenium (Se), iron (Fe), zinc (Zn), nickel (Ni), copper (Cu), chromium (Cr), cadmium (Cd), arsenic (As), and manganese (Mn) were measured in the blood.

Results:

Compared to the mild group, the NLR (P < 0.05) and the level of Se (P < 0.01), Fe (P < 0.05), and Zn (P < 0.05) were significantly decreased in the severe group. The level of Se, Fe, and Zn was significantly correlated to NLR levels. Furthermore, close positive correlation was found between NLR and severity of COVID-19.

Conclusion:

The micronutrient deficiency in the blood is associated with NLR in the severity of COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Neutrophils Type of study: Prognostic study Limits: Humans Language: English Journal: Int J Clin Pract Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: 2022

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Neutrophils Type of study: Prognostic study Limits: Humans Language: English Journal: Int J Clin Pract Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: 2022