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Lower probability and shorter duration of infections after COVID-19 vaccine correlate with anti-SARS-CoV-2 circulating IgGs.
Ronchini, Chiara; Gandini, Sara; Pasqualato, Sebastiano; Mazzarella, Luca; Facciotti, Federica; Mapelli, Marina; Frige', Gianmaria; Passerini, Rita; Pase, Luca; Capizzi, Silvio; Mastrilli, Fabrizio; Orecchia, Roberto; Natoli, Gioacchino; Pelicci, Pier Giuseppe.
  • Ronchini C; Clinical Genomics, European Institute of Oncology IRCCS, Milan, Italy.
  • Gandini S; Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.
  • Pasqualato S; Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.
  • Mazzarella L; Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.
  • Facciotti F; Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.
  • Mapelli M; Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.
  • Frige' G; Clinical Genomics, European Institute of Oncology IRCCS, Milan, Italy.
  • Passerini R; Division of Laboratory Medicine, European Institute of Oncology IRCCS, Milan, Italy.
  • Pase L; Occupational Medicine, European Institute of Oncology IRCCS, Milan, Italy.
  • Capizzi S; Medical Administration, CMO, IEO, European Institute of Oncology, IRCCS, Milan, Italy.
  • Mastrilli F; Medical Administration, CMO, IEO, European Institute of Oncology, IRCCS, Milan, Italy.
  • Orecchia R; Scientific Directorate, European Institute of Oncology IRCCS, Milan, Italy.
  • Natoli G; Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.
  • Pelicci PG; Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.
PLoS One ; 17(1): e0263014, 2022.
Article in English | MEDLINE | ID: covidwho-1662442
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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ABSTRACT
The correlation between immune responses and protection from SARS-CoV-2 infections and its duration remains unclear. We performed a sanitary surveillance at the European Institute of Oncology (IEO) in Milan over a 17 months period. Pre-vaccination, in 1,493 participants, we scored 266 infections (17.8%) and 8 possible reinfections (3%). Post-vaccination, we identified 30 infections in 2,029 vaccinated individuals (1.5%). We report that the probability of infection post-vaccination is i) significantly lower compared to natural infection, ii) associated with a significantly shorter median duration of infection than that of first infection and reinfection, iii) anticorrelated with circulating antibody levels.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / Antibodies, Anti-Idiotypic / COVID-19 Vaccines / COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2022 Document Type: Article Affiliation country: Journal.pone.0263014

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / Antibodies, Anti-Idiotypic / COVID-19 Vaccines / COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2022 Document Type: Article Affiliation country: Journal.pone.0263014