Microbiota regulation of viral infections through interferon signaling.
Trends Microbiol
; 30(8): 778-792, 2022 08.
Article
in English
| MEDLINE | ID: covidwho-1663909
ABSTRACT
The interferon (IFN) response is the major early innate immune response against invading viral pathogens and is even capable of mediating sterilizing antiviral immunity without the support of the adaptive immune system. Cumulative evidence suggests that the gut microbiota can modulate IFN responses, indirectly determining virological outcomes. This review outlines our current knowledge of the interactions between the gut microbiota and IFN responses and dissects the different mechanisms by which the gut microbiota may alter IFN expression to diverse viral infections. This knowledge offers a basis for translating experimental evidence from animal studies into the human context and identifies avenues for leveraging the gut microbiota-IFN-virus axis to improve control of viral infections and performance of viral vaccines.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Virus Diseases
/
Microbiota
Topics:
Vaccines
Limits:
Animals
/
Humans
Language:
English
Journal:
Trends Microbiol
Journal subject:
Microbiology
Year:
2022
Document Type:
Article
Affiliation country:
J.tim.2022.01.007
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