Research advances and prospects of legume lectins
Journal of Biosciences
; 46(4), 2021.
Article
in English
| EMBASE | ID: covidwho-1664506
ABSTRACT
Lectins are widely distributed proteins having ability of binding selectively and reversibly with carbohydrates moieties and glycoconjugates. Although lectins have been reported from different biological sources, the legume lectins are the best-characterized family of plant lectins. Legume lectins are a large family of homologous proteins with considerable similarity in amino acid sequence and their tertiary structures. Despite having strong sequence conservation, these lectins show remarkable variability in carbohydrate specificity and quaternary structures. The ability of legume lectins in recognizing glycans and glycoconjugates on cells and other intracellular structures make them a valuable research tool in glycomic research. Due to variability in binding with glycans, glycoconjugates and multiple biological functions, legume lectins are the subject of intense research for their diverse application in different fields such as glycobiology, biomedical research and crop improvement. The present review specially focuses on structural and functional characteristics of legume lectins along with their potential areas of application.
biosensor; carbohydrate derivative; glycan; glycan derivative; glycoconjugate; plant lectin; affinity chromatography; amino acid sequence; antibacterial activity; antifungal activity; antineoplastic activity; antiviral activity; biological functions; biotechnology; cell structure; coronavirus disease 2019; crop improvement; drug activity; drug delivery system; entomotoxic activity; enzyme linked lectin assay; glycobiology; glycomics; hemagglutination; histochemistry; human; immunoregulation; influenza; legume; malignant neoplasm; medical research; nonhuman; plant development; plant growth; protein analysis; protein binding; protein carbohydrate interaction; protein family; protein function; protein glycosylation; protein localization; protein microarray; protein quaternary structure; protein structure; protein tertiary structure; review
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Journal of Biosciences
Year:
2021
Document Type:
Article
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