Your browser doesn't support javascript.
Exercise after influenza or COVID-19 vaccination increases serum antibody without an increase in side effects.
Hallam, Justus; Jones, Tyanez; Alley, Jessica; Kohut, Marian L.
  • Hallam J; Department of Kinesiology, Iowa State University, Ames, IA, USA; Program of Immunobiology, Iowa State University, Ames, IA, USA.
  • Jones T; Nanovaccine Institute, Iowa State University, Ames, IA, USA.
  • Alley J; Department of Kinesiology, Iowa State University, Ames, IA, USA; Program of Immunobiology, Iowa State University, Ames, IA, USA.
  • Kohut ML; Department of Kinesiology, Iowa State University, Ames, IA, USA; Program of Immunobiology, Iowa State University, Ames, IA, USA; Nanovaccine Institute, Iowa State University, Ames, IA, USA. Electronic address: mkohut@iastate.edu.
Brain Behav Immun ; 102: 1-10, 2022 05.
Article in English | MEDLINE | ID: covidwho-1664674
ABSTRACT
Vaccination is an effective public health measure, yet vaccine efficacy varies across different populations. Adjuvants improve vaccine efficacy but often increase reactogenicity. An unconventional behavioral "adjuvant" is physical exercise at the time of vaccination. Here, in separate experiments, we examined the effect of 90-minute light- to moderate-intensity cycle ergometer or outdoor walk/jog aerobic exercise performed once after immunization on serum antibody response to three different vaccines (2009 pandemic influenza H1N1, seasonal influenza, and COVID-19). Exercise took place after influenza vaccination or after the first dose of Pfizer-BioNTech COVID-19 vaccine. A mouse model of influenza A immunization was used to examine the effect of exercise on antibody response and the role of IFNα as a potential mechanism by treating mice with anti-IFNα antibody. The results show that 90 min of exercise consistently increased serum antibody to each vaccine four weeks post-immunization, and IFNα may partially contribute to the exercise-related benefit. Exercise did not increase side effects after the COVID-19 vaccination. These findings suggest that adults who exercise regularly may increase antibody response to influenza or COVID-19 vaccine by performing a single session of light- to moderate-intensity exercise post-immunization.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Drug-Related Side Effects and Adverse Reactions / Influenza, Human / Influenza A Virus, H1N1 Subtype / COVID-19 Type of study: Experimental Studies Topics: Vaccines Limits: Animals / Humans Language: English Journal: Brain Behav Immun Journal subject: Allergy and Immunology / Brain / Psychophysiology Year: 2022 Document Type: Article Affiliation country: J.bbi.2022.02.005

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Drug-Related Side Effects and Adverse Reactions / Influenza, Human / Influenza A Virus, H1N1 Subtype / COVID-19 Type of study: Experimental Studies Topics: Vaccines Limits: Animals / Humans Language: English Journal: Brain Behav Immun Journal subject: Allergy and Immunology / Brain / Psychophysiology Year: 2022 Document Type: Article Affiliation country: J.bbi.2022.02.005