Ultrasensitive and highly selective "turn-on" fluorescent sensor for the detection and measurement of melatonin in juice samples.
Chemosphere
; 295: 133869, 2022 May.
Article
in English
| MEDLINE | ID: covidwho-1664752
ABSTRACT
Melatonin (MLT), a hormone related to the regulation of brain functions, is directly related to sleep quality and is considered to be a possible adjuvant therapy for patients needing hospitalization for coronavirus disease 2019 pneumonia, and accurate measurement of MLT is crucial. Herein, a new, highly sensitive, and easy operation fluorescent probe was provided based on Zr metal-organic framework encapsulation into the molecularly imprinted polymer (MOF@MIP). By combining unique properties of MIP and fluorescent MOF, selectivity and operation of the applied method were significantly improved. Different characterization methods, such as XRD, FT-IR, and FE-SEM, were used to confirm the synthesis reliability. MOF@MIP was successfully used for the precise identification and ultrasensitive detection for trace amounts of MLT. The detection mechanism for the analytical system is based on the ''turn-on'' fluorescence (FL) signal in 404 nm. The findings proved that it is possible to detect trace amounts of MLT in real samples including grape, cherry, and sour cherry juice. The linear range and the limit of detection (LOD) for trace amounts of MLT were obtained as 1-100 ng/mL and 0.18 ng/mL, respectively.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Molecular Imprinting
/
COVID-19
/
Melatonin
Type of study:
Diagnostic study
Limits:
Humans
Language:
English
Journal:
Chemosphere
Year:
2022
Document Type:
Article
Affiliation country:
J.chemosphere.2022.133869
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