Your browser doesn't support javascript.
Circulating miR-320b and miR-483-5p levels are associated with COVID-19 in-hospital mortality.
Giuliani, Angelica; Matacchione, Giulia; Ramini, Deborah; Di Rosa, Mirko; Bonfigli, Anna Rita; Sabbatinelli, Jacopo; Monsurrò, Vladia; Recchioni, Rina; Marcheselli, Fiorella; Marchegiani, Francesca; Piacenza, Francesco; Cardelli, Maurizio; Galeazzi, Roberta; Pomponio, Giovanni; Ferrarini, Alessia; Gabrielli, Armando; Svegliati Baroni, Silvia; Moretti, Marco; Sarzani, Riccardo; Giordano, Piero; Cherubini, Antonio; Corsonello, Andrea; Antonicelli, Roberto; Procopio, Antonio Domenico; Ferracin, Manuela; Bonafè, Massimiliano; Lattanzio, Fabrizia; Olivieri, Fabiola.
  • Giuliani A; Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.
  • Matacchione G; Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.
  • Ramini D; Center of Clinical Pathology and Innovative Therapy, IRCCS INRCA, Ancona, Italy.
  • Di Rosa M; Center of Clinical Pathology and Innovative Therapy, IRCCS INRCA, Ancona, Italy.
  • Bonfigli AR; Scientific Direction and Geriatric Unit, IRCCS INRCA, Ancona, Italy.
  • Sabbatinelli J; Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy; SOD Medicina di Laboratorio, Azienda Ospedaliero Universitaria Ospedali Riuniti, Ancona, Italy. Electronic address: j.sabbatinelli@pm.univpm.it.
  • Monsurrò V; Department of Medicine, University of Verona, Verona, Italy.
  • Recchioni R; Center of Clinical Pathology and Innovative Therapy, IRCCS INRCA, Ancona, Italy.
  • Marcheselli F; Center of Clinical Pathology and Innovative Therapy, IRCCS INRCA, Ancona, Italy.
  • Marchegiani F; Center of Clinical Pathology and Innovative Therapy, IRCCS INRCA, Ancona, Italy.
  • Piacenza F; Advanced Technology Center for Aging Research, Scientific Technological Area, IRCCS INRCA, Ancona, Italy.
  • Cardelli M; Advanced Technology Center for Aging Research, Scientific Technological Area, IRCCS INRCA, Ancona, Italy.
  • Galeazzi R; Clinical Laboratory and Molecular Diagnostic, Italian National Research Center on Aging, IRCCS INRCA, Ancona, Italy.
  • Pomponio G; Clinica Medica, Department of Internal Medicine, Ospedali Riuniti, Ancona, Italy.
  • Ferrarini A; Clinica Medica, Department of Internal Medicine, Ospedali Riuniti, Ancona, Italy.
  • Gabrielli A; Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy; Clinica Medica, Department of Internal Medicine, Ospedali Riuniti, Ancona, Italy.
  • Svegliati Baroni S; Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.
  • Moretti M; SOD Medicina di Laboratorio, Azienda Ospedaliero Universitaria Ospedali Riuniti, Ancona, Italy.
  • Sarzani R; Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy; Internal Medicine and Geriatrics, Italian National Research Centre on Aging, Hospital "U. Sestilli", IRCCS INRCA, via della Montagnola n. 81, 60127, Ancona, Italy.
  • Giordano P; Internal Medicine and Geriatrics, Italian National Research Centre on Aging, Hospital "U. Sestilli", IRCCS INRCA, via della Montagnola n. 81, 60127, Ancona, Italy.
  • Cherubini A; Geriatria, Accettazione geriatrica e Centro di Ricerca Per l'invecchiamento, IRCCS INRCA, Ancona, Italy.
  • Corsonello A; Geriatric Medicine, IRCCS INRCA, 87100 Cosenza, Italy; Unit of Geriatric Pharmacoepidemiology and Biostatistics, IRCCS INRCA, 87100 Cosenza, Italy.
  • Antonicelli R; Cardiology Unit, IRCCS INRCA, 60129 Ancona, Italy.
  • Procopio AD; Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy; Clinical Laboratory and Molecular Diagnostic, Italian National Research Center on Aging, IRCCS INRCA, Ancona, Italy.
  • Ferracin M; Department of Experimental, Diagnostic, and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.
  • Bonafè M; Department of Experimental, Diagnostic, and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.
  • Lattanzio F; Scientific Direction and Geriatric Unit, IRCCS INRCA, Ancona, Italy.
  • Olivieri F; Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy; Center of Clinical Pathology and Innovative Therapy, IRCCS INRCA, Ancona, Italy.
Mech Ageing Dev ; 202: 111636, 2022 03.
Article in English | MEDLINE | ID: covidwho-1665255
ABSTRACT
The stratification of mortality risk in COVID-19 patients remains extremely challenging for physicians, especially in older patients. Innovative minimally invasive molecular biomarkers are needed to improve the prediction of mortality risk and better customize patient management. In this study, aimed at identifying circulating miRNAs associated with the risk of COVID-19 in-hospital mortality, we analyzed serum samples of 12 COVID-19 patients by small RNA-seq and validated the findings in an independent cohort of 116 COVID-19 patients by qRT-PCR. Thirty-four significantly deregulated miRNAs, 25 downregulated and 9 upregulated in deceased COVID-19 patients compared to survivors, were identified in the discovery cohort. Based on the highest fold-changes and on the highest expression levels, 5 of these 34 miRNAs were selected for the analysis in the validation cohort. MiR-320b and miR-483-5p were confirmed to be significantly hyper-expressed in deceased patients compared to survived ones. Kaplan-Meier and Cox regression models, adjusted for relevant confounders, confirmed that patients with the 20% highest miR-320b and miR-483-5p serum levels had three-fold increased risk to die during in-hospital stay for COVID-19. In conclusion, high levels of circulating miR-320b and miR-483-5p can be useful as minimally invasive biomarkers to stratify older COVID-19 patients with an increased risk of in-hospital mortality.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Hospital Mortality / MicroRNAs / Circulating MicroRNA / COVID-19 / Hospitalization Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Aged / Female / Humans / Male Language: English Journal: Mech Ageing Dev Year: 2022 Document Type: Article Affiliation country: J.mad.2022.111636

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Hospital Mortality / MicroRNAs / Circulating MicroRNA / COVID-19 / Hospitalization Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Aged / Female / Humans / Male Language: English Journal: Mech Ageing Dev Year: 2022 Document Type: Article Affiliation country: J.mad.2022.111636