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The Stability of an Isolate of the SARS-CoV-2 B.1.1.7 Lineage in Aerosols Is Similar to 3 Earlier Isolates.
Schuit, Michael; Biryukov, Jennifer; Beck, Katie; Yolitz, Jason; Bohannon, Jordan; Weaver, Wade; Miller, David; Holland, Brian; Krause, Melissa; Freeburger, Denise; Williams, Gregory; Wood, Stewart; Graham, Amanda; Rosovitz, M J; Bazinet, Adam; Phillips, Aaron; Lovett, Sean; Garcia, Karla; Abbott, Elliott; Wahl, Victoria; Ratnesar-Shumate, Shanna; Dabisch, Paul.
  • Schuit M; National Biodefense Analysis and Countermeasures Center, operated by Battelle National Biodefense Institute for the US Department of Homeland Security, Frederick, Maryland, USA.
  • Biryukov J; National Biodefense Analysis and Countermeasures Center, operated by Battelle National Biodefense Institute for the US Department of Homeland Security, Frederick, Maryland, USA.
  • Beck K; National Biodefense Analysis and Countermeasures Center, operated by Battelle National Biodefense Institute for the US Department of Homeland Security, Frederick, Maryland, USA.
  • Yolitz J; National Biodefense Analysis and Countermeasures Center, operated by Battelle National Biodefense Institute for the US Department of Homeland Security, Frederick, Maryland, USA.
  • Bohannon J; National Biodefense Analysis and Countermeasures Center, operated by Battelle National Biodefense Institute for the US Department of Homeland Security, Frederick, Maryland, USA.
  • Weaver W; National Biodefense Analysis and Countermeasures Center, operated by Battelle National Biodefense Institute for the US Department of Homeland Security, Frederick, Maryland, USA.
  • Miller D; National Biodefense Analysis and Countermeasures Center, operated by Battelle National Biodefense Institute for the US Department of Homeland Security, Frederick, Maryland, USA.
  • Holland B; National Biodefense Analysis and Countermeasures Center, operated by Battelle National Biodefense Institute for the US Department of Homeland Security, Frederick, Maryland, USA.
  • Krause M; National Biodefense Analysis and Countermeasures Center, operated by Battelle National Biodefense Institute for the US Department of Homeland Security, Frederick, Maryland, USA.
  • Freeburger D; National Biodefense Analysis and Countermeasures Center, operated by Battelle National Biodefense Institute for the US Department of Homeland Security, Frederick, Maryland, USA.
  • Williams G; National Biodefense Analysis and Countermeasures Center, operated by Battelle National Biodefense Institute for the US Department of Homeland Security, Frederick, Maryland, USA.
  • Wood S; National Biodefense Analysis and Countermeasures Center, operated by Battelle National Biodefense Institute for the US Department of Homeland Security, Frederick, Maryland, USA.
  • Graham A; National Biodefense Analysis and Countermeasures Center, operated by Battelle National Biodefense Institute for the US Department of Homeland Security, Frederick, Maryland, USA.
  • Rosovitz MJ; National Biodefense Analysis and Countermeasures Center, operated by Battelle National Biodefense Institute for the US Department of Homeland Security, Frederick, Maryland, USA.
  • Bazinet A; National Biodefense Analysis and Countermeasures Center, operated by Battelle National Biodefense Institute for the US Department of Homeland Security, Frederick, Maryland, USA.
  • Phillips A; National Biodefense Analysis and Countermeasures Center, operated by Battelle National Biodefense Institute for the US Department of Homeland Security, Frederick, Maryland, USA.
  • Lovett S; National Biodefense Analysis and Countermeasures Center, operated by Battelle National Biodefense Institute for the US Department of Homeland Security, Frederick, Maryland, USA.
  • Garcia K; National Biodefense Analysis and Countermeasures Center, operated by Battelle National Biodefense Institute for the US Department of Homeland Security, Frederick, Maryland, USA.
  • Abbott E; National Biodefense Analysis and Countermeasures Center, operated by Battelle National Biodefense Institute for the US Department of Homeland Security, Frederick, Maryland, USA.
  • Wahl V; National Biodefense Analysis and Countermeasures Center, operated by Battelle National Biodefense Institute for the US Department of Homeland Security, Frederick, Maryland, USA.
  • Ratnesar-Shumate S; National Biodefense Analysis and Countermeasures Center, operated by Battelle National Biodefense Institute for the US Department of Homeland Security, Frederick, Maryland, USA.
  • Dabisch P; National Biodefense Analysis and Countermeasures Center, operated by Battelle National Biodefense Institute for the US Department of Homeland Security, Frederick, Maryland, USA.
J Infect Dis ; 224(10): 1641-1648, 2021 11 22.
Article in English | MEDLINE | ID: covidwho-1665993
ABSTRACT

BACKGROUND:

Our laboratory previously examined the influence of environmental conditions on the stability of an early isolate of SARS-CoV-2 (hCoV-19/USA/WA-1/2020) in aerosols generated from culture medium or simulated saliva. However, genetic differences have emerged among SARS-CoV-2 lineages, and it is possible that these differences may affect environmental stability and the potential for aerosol transmission.

METHODS:

The influence of temperature, relative humidity, and simulated sunlight on the decay of 4 SARS-CoV-2 isolates in aerosols, including 1 belonging to the recently emerged B.1.1.7 lineage, were compared in a rotating drum chamber. Aerosols were generated from simulated respiratory tract lining fluid to represent aerosols originating from the deep lung.

RESULTS:

No differences in the stability of the isolates were observed in the absence of simulated sunlight at either 20°C or 40°C. However, a small but statistically significant difference in the stability was observed between some isolates in simulated sunlight at 20°C and 20% relative humidity.

CONCLUSIONS:

The stability of SARS-CoV-2 in aerosols does not vary greatly among currently circulating lineages, including B.1.1.7, suggesting that the increased transmissibility associated with recent SARS-CoV-2 lineages is not due to enhanced survival in the environment.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis