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Allergies and COVID-19 vaccines: An ENDA/EAACI Position paper.
Barbaud, Annick; Garvey, Lene Heise; Arcolaci, Alessandra; Brockow, Knut; Mori, Francesca; Mayorga, Cristobalina; Bonadonna, Patrizia; Atanaskovic-Markovic, Marina; Moral, Luis; Zanoni, Giovanna; Pagani, Mauro; Soria, Angèle; Jost, Maja; Caubet, Jean-Christoph; Carmo, Abreu; Mona, Al-Ahmad; Alvarez-Perea, Alberto; Bavbek, Sevim; Benedetta, Biagioni; Bilo, M Beatrice; Blanca-López, Natalia; Bogas, Herrera Gádor; Buonomo, Alessandro; Calogiuri, Gianfranco; Carli, Giulia; Cernadas, Josefina; Cortellini, Gabriele; Celik, Gülfem; Demir, Semra; Doña, Inmaculada; Dursun, Adile Berna; Eberlein, Bernadette; Faria, Emilia; Fernandes, Bryan; Garcez, Tomaz; Garcia-Nunez, Ignacio; Gawlik, Radoslaw; Gelincik, Asli; Gomes, Eva; Gooi, Jimmy H C; Grosber, Martine; Gülen, Theo; Hacard, Florence; Hoarau, Cyrille; Janson, Christer; Johnston, Sebastian L; Joerg, Lukas; Kepil Özdemir, Seçil; Klimek, Ludger; Kosnik, Mitja.
  • Barbaud A; Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP.Sorbonne Université, Hôpital Tenon, Département de dermatologie et allergologie, Paris, France.
  • Garvey LH; Allergy Clinic, Copenhagen University Hospital at Gentofte, Copenhagen, Denmark.
  • Arcolaci A; Department of Clinical Medicine, University of Copenhagen, Denmark.
  • Brockow K; Immunology Unit, University Hospital of Verona, Policlinico G.B. Rossi, Verona, Italy.
  • Mori F; Department of Dermatology and Allergy Biederstein, Faculty of Medicine, Technical University of Munich, Munich, Germany.
  • Mayorga C; Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital.
  • Bonadonna P; Allergy Clinical Unit, Hospital Regional Universitario de Málaga-Instituto de Investigación Biomédica de Málaga-IBIMA, ARADyAL, Málaga, Spain.
  • Atanaskovic-Markovic M; Allergy Unit, Verona University Hospital, Verona, Italy.
  • Moral L; Faculty of Medicine, University of Belgrade, University Children's Hospital, Belgrade, Serbia.
  • Zanoni G; Moral Luis. Pediatric Allergy and Respiratory Unit, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain.
  • Pagani M; Giovanna Zanoni, Immunology Unit, Policlinico G.B. Rossi, Azienda Ospedaliera Universitaria Integrata Verona, Italy.
  • Soria A; Medicine Department, Medicine Ward Mantova Hospital, ASST di Mantova, Italy.
  • Jost M; Sorbonne Université, INSERM 1135 Cimi-Paris, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Departement de dermatologie et d'allergologie, Paris, France.
  • Caubet JC; University Clinic of Respiratory and Allergic Diseases Golnik, Golnik, Slovenia.
  • Carmo A; Department of Women-Children-Teenagers, University Hospital of Geneva, Geneva, Switzerland.
  • Mona AA; Allergy and Clinical Immunology Unit, Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real and Allergy and Clinical Immunology Unit, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal.
  • Alvarez-Perea A; Microbiology Department, Faculty of Medicine, Kuwait University, Kuwait.
  • Bavbek S; Allergy Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
  • Benedetta B; School of Medicine, Department of Pulmonary Diseases, Division of Allergy, FAAAI, Ankara University, Ankara, Turkey.
  • Bilo MB; Division of Internal Medicine, Hepatobiliary and Immunoallergic Disease, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy.
  • Blanca-López N; Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.
  • Bogas HG; Allergy Unit - Department of Internal Medicine, University Hospital Ospedali Riuniti di Ancona, Italy.
  • Buonomo A; Infanta Leonor University Hospital, Madrid, Spain.
  • Calogiuri G; Allergy Research Group, Instituto de Investigación Biomédica de Málaga-IBIMA, and Allergy Unit, Hospital Regional Universitario de Málaga-HRUM, Málaga, Spain.
  • Carli G; Allergy Unit - Fondazione Policlinico Gemelli IRCCS - Largo Gemelli, Rome, Italy.
  • Cernadas J; Hospital Vito Fazzi, Lecce, Italy.
  • Cortellini G; SOS Allergologia e Immunologia, Azienda USL Toscana Centro, Ospedale S. Stefano, Prato, Italy.
  • Celik G; Allergy and Clinical Immunology Department, Centro Hospitalar Universitário de S. João, Porto and Allergy Unit, Hospital Lusíadas, Porto, Portugal.
  • Demir S; Allergy Unit, Departments of Internal Medicine, Azienda Sanitaria della Romagna, Rimini, Hospital, Rimini, Italy.
  • Doña I; Department of Chest Diseases, Division of Immunology and allergy, Ankara University School of Medicine cebeci Hospital, Ankara, Turkey.
  • Dursun AB; Istanbul University, Istanbul Faculty of Medicine, Internal Medicine, Immunology and Allergic Diseases, Istanbul, Turkey.
  • Eberlein B; Allergy Research Group, Allergy Unit, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga-IBIMA, Plaza del Hospital Civil s/n, Málaga, Spain.
  • Faria E; Department of Adult Allergy, Memorial Ankara Hospital, Ankara, Turkey.
  • Fernandes B; Faculty of Medicine, Department of Dermatology and Allergy Biederstein, Technical University of Munich, Munich, Germany.
  • Garcez T; Allergy and Clinical Immunology Unit, Centro Hospitalar E Universitário de Coimbra, Coimbra, Portugal.
  • Garcia-Nunez I; Barts Health NHS Trust, St Bartholomew's Hospital, London, UK.
  • Gawlik R; Immunology Department, Manchester University NHS Foundation Trust, Manchester, UK.
  • Gelincik A; Hospital Quironsalud Cordoba, Cordoba, Spain.
  • Gomes E; Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, Katowice, Poland.
  • Gooi JHC; Istanbul University, Istanbul Faculty of Medicine, Internal Medicine, Immunology and Allergic Diseases, Istanbul, Turkey.
  • Grosber M; Allergy Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.
  • Gülen T; Department of Clinical Immunology, King's College Hospital, London, UK.
  • Hacard F; Department of Dermatology, Universitair Ziekenhuis, Vrije Universiteit Brussel, Brussel, Belgium.
  • Hoarau C; Department of Respiratory Medicine and Allergy, Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden.
  • Janson C; Allergology and Clinical Immunology Department, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France.
  • Johnston SL; Service transversal d'allergologie et immunologie clinique, CHR de Tours, Tours, France.
  • Joerg L; Department of Medical Sciences, Uppsala university, Sweden.
  • Kepil Özdemir S; National Heart and Lung Institute, Imperial College London, London, UK.
  • Klimek L; Division of Allergology and Clinical Immunology, Department of Pneumology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Kosnik M; Department of Chest Diseases, Division of Allergy and Immunology, Chest Diseases and Surgery Training and Research Hospital, Izmir, Turkey.
Allergy ; 77(8): 2292-2312, 2022 08.
Article in English | MEDLINE | ID: covidwho-1666277
ABSTRACT

BACKGROUND:

Anaphylaxis, which is rare, has been reported after COVID-19 vaccination, but its management is not standardized.

METHOD:

Members of the European Network for Drug Allergy and the European Academy of Allergy and Clinical Immunology interested in drug allergy participated in an online questionnaire on pre-vaccination screening and management of allergic reactions to COVID-19 vaccines, and literature was analysed.

RESULTS:

No death due to anaphylaxis to COVID-19 vaccines has been confirmed in scientific literature. Potential allergens, polyethylene glycol (PEG), polysorbate and tromethamine are excipients. The authors propose allergy evaluation of persons with the following histories 1-anaphylaxis to injectable drug or vaccine containing PEG or derivatives; 2-anaphylaxis to oral/topical PEG containing products; 3-recurrent anaphylaxis of unknown cause; 4-suspected or confirmed allergy to any mRNA vaccine; and 5-confirmed allergy to PEG or derivatives. We recommend a prick-to-prick skin test with the left-over solution in the suspected vaccine vial to avoid waste. Prick test panel should include PEG 4000 or 3500, PEG 2000 and polysorbate 80. The value of in vitro test is arguable.

CONCLUSIONS:

These recommendations will lead to a better knowledge of the management and mechanisms involved in anaphylaxis to COVID-19 vaccines and enable more people with history of allergy to be vaccinated.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / Drug Hypersensitivity / COVID-19 Vaccines / COVID-19 / Anaphylaxis Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Allergy Year: 2022 Document Type: Article Affiliation country: All.15241

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / Drug Hypersensitivity / COVID-19 Vaccines / COVID-19 / Anaphylaxis Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Allergy Year: 2022 Document Type: Article Affiliation country: All.15241