Trajectories of hypoxemia and pulmonary mechanics of COVID-19 ARDS in the NorthCARDS dataset.
BMC Pulm Med
; 22(1): 51, 2022 Feb 04.
Article
in English
| MEDLINE | ID: covidwho-1666648
ABSTRACT
BACKGROUND:
Understandingâ¯heterogeneity seen in patients withâ¯COVIDARDS and comparing to non-COVIDARDSâ¯may inform tailored treatments.METHODS:
A multidisciplinary team of frontline clinicians and data scientists worked to create the Northwell COVIDARDS dataset (NorthCARDS) leveraging overâ¯11,542â¯COVID-19 hospital admissions.â¯Theâ¯dataâ¯was then summarizedâ¯toâ¯examineâ¯descriptiveâ¯differencesâ¯based on clinically meaningful categories of lung compliance, and to examine trends in oxygenation.FINDINGS:
Of the 1536 COVIDARDS patients in the NorthCARDS dataset, there were 531 (34.6%) who had very low lung compliance (< 20 ml/cmH2O), 970 (63.2%) with low-normal compliance (20-50 ml/cmH2O), and 35 (2.2%) with high lung compliance (> 50 ml/cmH2O). The very low compliance group had double the median time to intubation compared to the low-normal group (107.3 h (IQR 25.8, 239.2) vs. 39.5 h (IQR 5.4, 91.6)). Overall, 68.8% (n = 1057) of the patients died during hospitalization. In comparison to non-COVIDARDS reports, there were less patients in the high compliance category (2.2% vs. 12%, compliance ≥ 50 mL/cmH20), and more patients with P/F ≤ 150 (59.8% vs. 45.6%). There is a statistically significant correlation between compliance and P/F ratio. The Oxygenation Index is the highest in the very low compliance group (12.51, SD(6.15)), and lowest in high compliance group (8.78, SD(4.93)).CONCLUSIONS:
The respiratory system compliance distribution of COVIDARDS is similar to non-COVIDARDS. In some patients, there may be a relation between time to intubation and duration of high levels of supplemental oxygen treatment on trajectory of lung compliance.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiratory Distress Syndrome
/
COVID-19
/
Lung
/
Hypoxia
Type of study:
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
BMC Pulm Med
Year:
2022
Document Type:
Article
Affiliation country:
S12890-021-01732-Y
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