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Efficacy of lopinavir-ritonavir combination therapy for the treatment of hospitalized COVID-19 patients: a meta-analysis.
Deng, Jiawen; Zhou, Fangwen; Hou, Wenteng; Heybati, Kiyan; Ali, Saif; Chang, Oswin; Silver, Zachary; Dhivagaran, Thanansayan; Ramaraju, Harikrishnaa Ba; Wong, Chi Yi; Zuo, Qi Kang; Lapshina, Elizabeth; Mellett, Madeline.
  • Deng J; Faculty of Health Sciences, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4L8, Canada.
  • Zhou F; Faculty of Health Sciences, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4L8, Canada.
  • Hou W; Faculty of Health Sciences, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4L8, Canada.
  • Heybati K; Faculty of Health Sciences, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4L8, Canada.
  • Ali S; Mayo Clinic Alix School of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
  • Chang O; Faculty of Health Sciences, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4L8, Canada.
  • Silver Z; Faculty of Health Sciences, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4L8, Canada.
  • Dhivagaran T; Faculty of Science, Carleton University, 1125 Colonel By Dr, Ottawa, ON, K1S 5B6, Canada.
  • Ramaraju HB; Faculty of Health Sciences, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4L8, Canada.
  • Wong CY; Integrated Biomedical Engineering & Health Sciences Program, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4L8, Canada.
  • Zuo QK; Faculty of Health Sciences, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4L8, Canada.
  • Lapshina E; Faculty of Health Sciences, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4L8, Canada.
  • Mellett M; Department of Anesthesiology, Rutgers, New Jersey Medical School, 185 S Orange Ave, Newark, NJ 07103, USA.
Future Virol ; 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1666912
ABSTRACT

Aim:

To evaluate the efficacy and safety of lopinavir-ritonavir (LPV/r) therapy in treating hospitalized COVID-19 patients. Materials &

methods:

Data from randomized and observational studies were included in meta-analyses. Primary outcomes were length of stay, time for SARS-CoV-2 test conversion, mortality, incidence of mechanical ventilation, time to body temperature normalization and incidence of adverse events.

Results:

Twenty-four studies (n = 10,718) were included. LPV/r demonstrated no significant benefit over the control groups in all efficacy outcomes. The use of LPV/r was associated with a significant increase in the odds of adverse events.

Conclusion:

Given the lack of efficacy and increased incidence of adverse events, the clinical use of LPV/r in hospitalized COVID-19 patients is not recommended.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Randomized controlled trials / Reviews Language: English Year: 2021 Document Type: Article Affiliation country: Fvl-2021-0066

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Randomized controlled trials / Reviews Language: English Year: 2021 Document Type: Article Affiliation country: Fvl-2021-0066