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New Insights into the Role of the Complement System in Human Viral Diseases.
Ostrycharz, Ewa; Hukowska-Szematowicz, Beata.
  • Ostrycharz E; Institute of Biology, University of Szczecin, 71-412 Szczecin, Poland.
  • Hukowska-Szematowicz B; Doctoral School of the University of Szczecin, University of Szczecin, 71-412 Szczecin, Poland.
Biomolecules ; 12(2)2022 01 28.
Article in English | MEDLINE | ID: covidwho-1667042
ABSTRACT
The complement system (CS) is part of the human immune system, consisting of more than 30 proteins that play a vital role in the protection against various pathogens and diseases, including viral diseases. Activated via three pathways, the classical pathway (CP), the lectin pathway (LP), and the alternative pathway (AP), the complement system leads to the formation of a membrane attack complex (MAC) that disrupts the membrane of target cells, leading to cell lysis and death. Due to the increasing number of reports on its role in viral diseases, which may have implications for research on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), this review aims to highlight significant progress in understanding and defining the role of the complement system in four groups of diseases of viral etiology (1) respiratory diseases; (2) acute liver failure (ALF); (3) disseminated intravascular coagulation (DIC); and (4) vector-borne diseases (VBDs). Some of these diseases already present a serious global health problem, while others are a matter of concern and require the collaboration of relevant national services and scientists with the World Health Organization (WHO) to avoid their spread.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / Complement System Proteins Type of study: Etiology study / Experimental Studies / Randomized controlled trials Limits: Animals / Humans Language: English Year: 2022 Document Type: Article Affiliation country: Biom12020226

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / Complement System Proteins Type of study: Etiology study / Experimental Studies / Randomized controlled trials Limits: Animals / Humans Language: English Year: 2022 Document Type: Article Affiliation country: Biom12020226