Maternal Death by COVID-19 Associated with Elevated Troponin T Levels.
Viruses
; 14(2)2022 01 28.
Article
in English
| MEDLINE | ID: covidwho-1667343
ABSTRACT
Cardiomyocyte injury and troponin T elevation has been reported within COVID-19 patients and are associated with a worse prognosis. Limited data report this association among COVID-19 pregnant patients. OBJECTIVE:
We aimed to analyze the association between troponin T levels in severe COVID-19 pregnant women and risk of viral sepsis, intensive care unit (ICU) admission, or maternal death.METHODS:
We performed a prospective cohort of all obstetrics emergency admissions from a Mexican National Institute. All pregnant women diagnosed by reverse transcription-polymerase chain reaction (RT-qPCR) for SARS-CoV-2 infection between October 2020 and May 2021 were included. Clinical data were collected, and routine blood samples were obtained at hospital admission. Seric troponin T was measured at admission.RESULTS:
From 87 included patients, 31 (35.63%) had severe COVID-19 pneumonia, and 6 (6.89%) maternal deaths. ROC showed a significant relationship between troponin T and maternal death (AUC 0.979, CI 0.500-1.000). At a cutoff point of 7 ng/mL the detection rate for severe pneumonia was 83.3% (95%CI 0.500-0.100) at 10% false-positive rate.CONCLUSION:
COVID-19 pregnant women with elevated levels of troponin T present a higher risk of death and severe pneumonia.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia
/
Pregnancy Complications, Infectious
/
Maternal Mortality
/
Troponin T
/
COVID-19
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Country/Region as subject:
Mexico
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
V14020271
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