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Maternal Death by COVID-19 Associated with Elevated Troponin T Levels.
Torres-Torres, Johnatan; Martinez-Portilla, Raigam Jafet; Espino Y Sosa, Salvador; Solis-Paredes, Juan Mario; Hernández-Pacheco, Jose Antonio; Mateu-Rogell, Paloma; Cravioto-Sapien, Anette; Zamora-Madrazo, Adolfo; Estrada-Gutierrez, Guadalupe; Nares-Torices, Miguel Angel; Becerra-Navarro, Norma Patricia; Medina-Jimenez, Virginia; Villafan-Bernal, Jose Rafael; Rojas-Zepeda, Lourdes; Loya-Diaz, Diana Hipolita; Casillas-Barrera, Manuel.
  • Torres-Torres J; Clinical Research Branch, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City 11000, Mexico.
  • Martinez-Portilla RJ; ABC Medical Center, Medical Association, Mexico City 05330, Mexico.
  • Espino Y Sosa S; Iberoamerican Research Network in Obstetrics, Gynecology and Translational Medicine, Mexico City 06720, Mexico.
  • Solis-Paredes JM; Clinical Research Branch, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City 11000, Mexico.
  • Hernández-Pacheco JA; ABC Medical Center, Medical Association, Mexico City 05330, Mexico.
  • Mateu-Rogell P; Iberoamerican Research Network in Obstetrics, Gynecology and Translational Medicine, Mexico City 06720, Mexico.
  • Cravioto-Sapien A; Clinical Research Branch, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City 11000, Mexico.
  • Zamora-Madrazo A; ABC Medical Center, Medical Association, Mexico City 05330, Mexico.
  • Estrada-Gutierrez G; Iberoamerican Research Network in Obstetrics, Gynecology and Translational Medicine, Mexico City 06720, Mexico.
  • Nares-Torices MA; Clinical Research Branch, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City 11000, Mexico.
  • Becerra-Navarro NP; Clinical Research Branch, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City 11000, Mexico.
  • Medina-Jimenez V; Clinical Research Branch, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City 11000, Mexico.
  • Villafan-Bernal JR; Iberoamerican Research Network in Obstetrics, Gynecology and Translational Medicine, Mexico City 06720, Mexico.
  • Rojas-Zepeda L; Clinical Research Branch, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City 11000, Mexico.
  • Loya-Diaz DH; Clinical Research Branch, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City 11000, Mexico.
  • Casillas-Barrera M; Clinical Research Branch, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City 11000, Mexico.
Viruses ; 14(2)2022 01 28.
Article in English | MEDLINE | ID: covidwho-1667343
ABSTRACT
Cardiomyocyte injury and troponin T elevation has been reported within COVID-19 patients and are associated with a worse prognosis. Limited data report this association among COVID-19 pregnant patients.

OBJECTIVE:

We aimed to analyze the association between troponin T levels in severe COVID-19 pregnant women and risk of viral sepsis, intensive care unit (ICU) admission, or maternal death.

METHODS:

We performed a prospective cohort of all obstetrics emergency admissions from a Mexican National Institute. All pregnant women diagnosed by reverse transcription-polymerase chain reaction (RT-qPCR) for SARS-CoV-2 infection between October 2020 and May 2021 were included. Clinical data were collected, and routine blood samples were obtained at hospital admission. Seric troponin T was measured at admission.

RESULTS:

From 87 included patients, 31 (35.63%) had severe COVID-19 pneumonia, and 6 (6.89%) maternal deaths. ROC showed a significant relationship between troponin T and maternal death (AUC 0.979, CI 0.500-1.000). At a cutoff point of 7 ng/mL the detection rate for severe pneumonia was 83.3% (95%CI 0.500-0.100) at 10% false-positive rate.

CONCLUSION:

COVID-19 pregnant women with elevated levels of troponin T present a higher risk of death and severe pneumonia.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Pregnancy Complications, Infectious / Maternal Mortality / Troponin T / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Pregnancy Country/Region as subject: Mexico Language: English Year: 2022 Document Type: Article Affiliation country: V14020271

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Pregnancy Complications, Infectious / Maternal Mortality / Troponin T / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Pregnancy Country/Region as subject: Mexico Language: English Year: 2022 Document Type: Article Affiliation country: V14020271