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Cytokine storm in COVID-19: from viral infection to immune responses, diagnosis and therapy.
Jiang, Yizhou; Rubin, Limor; Peng, Tangming; Liu, Linlin; Xing, Xingan; Lazarovici, Philip; Zheng, Wenhua.
  • Jiang Y; Center of Reproduction, Development & Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.
  • Rubin L; Allergy and Clinical Immunology Unit, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
  • Peng T; Center of Reproduction, Development & Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.
  • Liu L; Center of Reproduction, Development & Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.
  • Xing X; Center of Reproduction, Development & Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.
  • Lazarovici P; School of Pharmacy Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.
  • Zheng W; Center of Reproduction, Development & Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.
Int J Biol Sci ; 18(2): 459-472, 2022.
Article in English | MEDLINE | ID: covidwho-1667649
ABSTRACT
The COVID-19 outbreak is emerging as a significant public health challenge. Excessive production of proinflammatory cytokines, also known as cytokine storm, is a severe clinical syndrome known to develop as a complication of infectious or inflammatory diseases. Clinical evidence suggests that the occurrence of cytokine storm in severe acute respiratory syndrome secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is closely associated with the rapid deterioration and high mortality of severe cases. In this review, we aim to summarize the mechanism of SARS-CoV-2 infection and the subsequent immunological events related to excessive cytokine production and inflammatory responses associated with ACE2-AngII signaling. An overview of the diagnosis and an update on current therapeutic regimens and vaccinations is also provided.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Int J Biol Sci Journal subject: Biology Year: 2022 Document Type: Article Affiliation country: Ijbs.59272

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Long Covid / Vaccines Limits: Humans Language: English Journal: Int J Biol Sci Journal subject: Biology Year: 2022 Document Type: Article Affiliation country: Ijbs.59272