Your browser doesn't support javascript.
The Pathogenetic Dilemma of Post-COVID-19 Mucormycosis in India.
Chakrabarti, Sankha Shubhra; Kaur, Upinder; Aggarwal, Sushil Kumar; Kanakan, Ahalya; Saini, Adesh; Agrawal, Bimal Kumar; Jin, Kunlin; Chakrabarti, Sasanka.
  • Chakrabarti SS; 1Department of Geriatric Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.
  • Kaur U; 2Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.
  • Aggarwal SK; 3Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.
  • Kanakan A; 4Department of Geriatric Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.
  • Saini A; 5Department of Biotechnology, Maharishi Markandeshwar (deemed to be) University, Mullana, Haryana, India.
  • Agrawal BK; 6Department of Medicine, Maharishi Markandeshwar (deemed to be) University, Mullana, Haryana, India.
  • Jin K; 7Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA.
  • Chakrabarti S; 8Department of Biochemistry and Central Research Cell, Maharishi Markandeshwar (deemed to be) University, Mullana, Haryana, India.
Aging Dis ; 13(1): 24-28, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1667758
ABSTRACT
There has been a surge of mucormycosis cases in India in the wake of the second wave of COVID-19 with more than 40000 cases reported. Mucormycosis in patients of COVID-19 in India is at variance to other countries where Aspergillus, Pneumocystis, and Candida have been reported to be the major secondary fungal pathogens. We discuss the probable causes of the mucormycosis epidemic in India. Whereas dysglycaemia and inappropriate steroid use have been widely suggested as tentative reasons, we explore other biological, iatrogenic, and environmental factors. The likelihood of a two-hit pathogenesis remains strong. We propose that COVID-19 itself provides the predisposition to invasive mucormycosis (first hit), through upregulation of GRP78 and downregulation of spleen tyrosine kinase involved in anti-fungal defense, as also through inhibition of CD8+ T-cell mediated immunity. The other iatrogenic and environmental factors may provide the second hit which may have resulted in the surge.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Topics: Long Covid Language: English Journal: Aging Dis Year: 2022 Document Type: Article Affiliation country: AD.2021.0811

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Topics: Long Covid Language: English Journal: Aging Dis Year: 2022 Document Type: Article Affiliation country: AD.2021.0811