Your browser doesn't support javascript.
Isolation of multidrug resistant bacterial pathogens and screening against Coleus amboinicus L. extracts
Annals of Phytomedicine-an International Journal ; 10(2):409-415, 2021.
Article in English | Web of Science | ID: covidwho-1667890
ABSTRACT
World health organisation (WHO) has declared antimicrobial resistance as a global crisis. Antimicrobial resistance is an emerging issue following the COVID-19. The development of novel antibiotics has become necessary for the treatment of MDR infections. Plants serve as a potential source for developing novel drugs, and herbal-based drugs are often safe. Therefore, the present study focuses on evaluating the antiMDR bacterial activity of Coleus amboinicus L. against multidrug-resistant Escherichia coli and Staphylococcus aureus. The clinical pathogens were collected and an antibiotic susceptibility test was performed using standard antibiotics to evaluate the resistant pattern of the pathogens. Bioactive compounds of the C. amboinicus leaves were extracted using methanol as solvent. DPPH radical scavenging activity and ferric reducing antioxidant power assay were performed. The antibacterial activity and minimum inhibitory concentration (MIC) of the leaf extract against isolated MDR pathogens were investigated. Crude plant extract showed better antioxidant values, 69.31 +/- 0.69% of DPPH scavenging and 78.35 +/- 0.32% of reducing power was observed on 1000 mu g of extract. 500 mg/ml and 1000 mg/ml showed higher zones against both the test organisms. MIC of E. coli and S. aureus was found to be 15.6 mg and 7.8 mg. From the analysis, bioactive compounds from C. amboinicus showed evident antibacterial activity against MDR pathogens and, therefore can be used for the development of antimicrobial drugs for the treatment of MDR infections.
Keywords

Full text: Available Collection: Databases of international organizations Database: Web of Science Language: English Journal: Annals of Phytomedicine-an International Journal Year: 2021 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: Databases of international organizations Database: Web of Science Language: English Journal: Annals of Phytomedicine-an International Journal Year: 2021 Document Type: Article