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Complexation of pillar[5]arene-based schiff bases with methylene blue: formation of binary complexes with improved anticancer activity
Journal of Molecular Structure ; : 132588, 2022.
Article in English | ScienceDirect | ID: covidwho-1670923
ABSTRACT
Cocktail therapy is one of the leading approaches for treating some complex diseases. Herein, a pH-triggered supramolecular cocktail drug delivery system assembled by the medium-strength complexes of pillar[5]arene-based schiff base (P5SB) with methylene blue (MB). Molecular modeling suggest that noncovalent interactions between schiff base side chain of P5SB and MB were mainly responsible for the stability of the complex. The amphiphilic P5SB⊃MB complex assembled into stable vesicles with an average diameter of 244.1 nm in conventional physiological environment (pH=7.4). Drug loading experiments demonstrated that doxorubicin (DOX) could be efficiently encapsulated into the hollow vesicles, and the drug would be rapidly released under acidic environment (pH=6.0). Moreover, the anti-cancer efficiency of DOX-loaded P5SB⊃MB vesicles was significantly enhanced because of the synergistic effect of P5SB, MB and DOX. Nonetheless, the live-cell imaging property of DOX was maintained after encapsulation.
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Full text: Available Collection: Databases of international organizations Database: ScienceDirect Language: English Journal: Journal of Molecular Structure Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: ScienceDirect Language: English Journal: Journal of Molecular Structure Year: 2022 Document Type: Article