Microbes and Parkinson's disease: from associations to mechanisms.
Trends Microbiol
; 30(8): 749-760, 2022 08.
Article
in English
| MEDLINE | ID: covidwho-1671203
ABSTRACT
Parkinson's disease (PD) is a neurodegenerative disorder influenced by both genetic and environmental factors. The mechanisms leading to neurodegeneration in PD are still under investigation, with several mechanistic models currently proposed. A number of microorganisms have been associated with increased risk of PD in humans, and recent research using newly developed models has begun to elucidate how these microbes may factor into disease development. Newly identified roles for PD-associated genes in host-microbe interactions and response to infections have also recently been uncovered, providing further evidence for microbial contributions to PD. Here we summarize these recent advances in the field and discuss them in the context of both historical and emerging hypotheses for PD development, with a particular focus on the application of rodent models as systems allowing for mechanistic hypothesis testing.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Parkinson Disease
/
Neurodegenerative Diseases
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Trends Microbiol
Journal subject:
Microbiology
Year:
2022
Document Type:
Article
Affiliation country:
J.tim.2022.01.004
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