Fc effector cross-reactivity: A hidden arsenal against SARS-CoV-2's evasive maneuvering.

Grunst, Michael W; Uchil, Pradeep D

Grunst, Michael W; Uchil, Pradeep D.

Grunst MW; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06510, USA.
Uchil PD; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06510, USA.

Cell Rep Med ; 3(2): 100540, 2022 02 15.

Article in English | MEDLINE | ID: covidwho-1671308

ABSTRACT

ABSTRACT

It is unclear whether SARS-CoV-2 VOCs differentially escape Fc effector functions of antibodies in addition to neutralization. In this issue of Cell Reports Medicine, Richardson et al.1 show that VOCs differ both in their ability to evade as well as elicit cross-reactive Fc-effector functions.

Subject(s)

Antibodies, Neutralizing/immunology; Antibodies, Viral/immunology; COVID-19/immunology; Immune Evasion/genetics; Immunoglobulin Fc Fragments/immunology; Mutation; SARS-CoV-2/genetics; SARS-CoV-2/immunology; COVID-19/virology; Cross Reactions; Humans; Spike Glycoprotein, Coronavirus/genetics; Spike Glycoprotein, Coronavirus/immunology

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin Fc Fragments / Antibodies, Neutralizing / Immune Evasion / SARS-CoV-2 / COVID-19 / Antibodies, Viral / Mutation Type of study: Experimental Studies / Randomized controlled trials Topics: Variants Limits: Humans Language: English Journal: Cell Rep Med Year: 2022 Document Type: Article Affiliation country: J.xcrm.2022.100540

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