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De Novo Vogt-Koyanagi-Harada Disease following Covid-19 Vaccine: A Case Report and Literature Overview.
Brunet de Courssou, Jean-Baptiste; Tisseyre, Mylène; Hadjadj, Jérôme; Chouchana, Laurent; Broca, Florent; Terrier, Benjamin; Duraffour, Pierre; Henriquez, Soledad.
  • Brunet de Courssou JB; Service de Médicine Interne, Centre de Référence des Maladies Auto-immunes Systémiques Rares, Hôpital Cochin, AP-HP, APHP-CUP, Paris, France.
  • Tisseyre M; Département de Pharmacologie, Centre Régional de Pharmacovigilance, Hôpital Cochin, AP-HP, APHP-CUP, Paris, France.
  • Hadjadj J; Service de Médicine Interne, Centre de Référence des Maladies Auto-immunes Systémiques Rares, Hôpital Cochin, AP-HP, APHP-CUP, Paris, France.
  • Chouchana L; Faculté de médecine, Université de Paris, Paris, France.
  • Broca F; Imagine Institute, Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, INSERM UMR 1163, Paris, France.
  • Terrier B; Département de Pharmacologie, Centre Régional de Pharmacovigilance, Hôpital Cochin, AP-HP, APHP-CUP, Paris, France.
  • Duraffour P; Service de Médicine Interne, Centre de Référence des Maladies Auto-immunes Systémiques Rares, Hôpital Cochin, AP-HP, APHP-CUP, Paris, France.
  • Henriquez S; Service de Médicine Interne, Centre de Référence des Maladies Auto-immunes Systémiques Rares, Hôpital Cochin, AP-HP, APHP-CUP, Paris, France.
Ocul Immunol Inflamm ; 30(5): 1292-1295, 2022 Jul.
Article in English | MEDLINE | ID: covidwho-1671885
ABSTRACT

PURPOSE:

To describe a case of Vogt-Koyanagi-Harada (VKH) disease after a Covid-19 mRNA vaccine (tozinameran) and to present the results of a pharmacovigilance disproportionality study.

METHODS:

A retrospective chart review and a pharmacovigilance disproportionality study using the WHO global individual case safety reports database (VigiBase).

RESULTS:

A 57-year-old female with no medical history developed a VKH disease 3 weeks after Covid-19 mRNA vaccine. Symptoms at onset were headaches and blurred vision associated with aseptic meningitis and bilateral diffuse granulomatous panuveitis with serous retinal detachment. One month from diagnosis and glucocorticoids treatment, the patient recovered. Five similar cases have been reported in VigiBase. VKH disease is disproportionately reported with tozinameran and other vaccines.

CONCLUSION:

VKH disease is disproportionately reported with tozinameran, suggesting a possible safety signal. Cases after vaccination support the screening for any possible immune triggers such as vaccines when assessing patients with VKH disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Panuveitis / Uveomeningoencephalitic Syndrome / COVID-19 Type of study: Case report / Diagnostic study / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Female / Humans / Middle aged Language: English Journal: Ocul Immunol Inflamm Journal subject: Allergy and Immunology / Ophthalmology Year: 2022 Document Type: Article Affiliation country: 09273948.2022.2028291

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Panuveitis / Uveomeningoencephalitic Syndrome / COVID-19 Type of study: Case report / Diagnostic study / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Female / Humans / Middle aged Language: English Journal: Ocul Immunol Inflamm Journal subject: Allergy and Immunology / Ophthalmology Year: 2022 Document Type: Article Affiliation country: 09273948.2022.2028291