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Persistence, Magnitude, and Patterns of Postacute Symptoms and Quality of Life Following Onset of SARS-CoV-2 Infection: Cohort Description and Approaches for Measurement.
Peluso, Michael J; Kelly, J Daniel; Lu, Scott; Goldberg, Sarah A; Davidson, Michelle C; Mathur, Sujata; Durstenfeld, Matthew S; Spinelli, Matthew A; Hoh, Rebecca; Tai, Viva; Fehrman, Emily A; Torres, Leonel; Hernandez, Yanel; Williams, Meghann C; Arreguin, Mireya I; Ngo, Lynn H; Deswal, Monika; Munter, Sadie E; Martinez, Enrique O; Anglin, Khamal A; Romero, Mariela D; Tavs, Jacqueline; Rugart, Paulina R; Chen, Jessica Y; Sans, Hannah M; Murray, Victoria W; Ellis, Payton K; Donohue, Kevin C; Massachi, Jonathan A; Weiss, Jacob O; Mehdi, Irum; Pineda-Ramirez, Jesus; Tang, Alex F; Wenger, Megan A; Assenzio, Melissa T; Yuan, Yan; Krone, Melissa R; Rutishauser, Rachel L; Rodriguez-Barraquer, Isabel; Greenhouse, Bryan; Sauceda, John A; Gandhi, Monica; Scheffler, Aaron Wolfe; Hsue, Priscilla Y; Henrich, Timothy J; Deeks, Steven G; Martin, Jeffrey N.
  • Peluso MJ; Division of HIV, Infectious Diseases, and Global Medicine, Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA.
  • Kelly JD; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Lu S; Institute of Global Health Sciences, University of California, San Francisco, San Francisco, California, USA.
  • Goldberg SA; F.I. Proctor Foundation, University of California, San Francisco, San Francisco, California, USA.
  • Davidson MC; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Mathur S; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Durstenfeld MS; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Spinelli MA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Hoh R; Division of Cardiology, Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA.
  • Tai V; Division of HIV, Infectious Diseases, and Global Medicine, Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA.
  • Fehrman EA; Division of HIV, Infectious Diseases, and Global Medicine, Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA.
  • Torres L; Division of HIV, Infectious Diseases, and Global Medicine, Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA.
  • Hernandez Y; Division of HIV, Infectious Diseases, and Global Medicine, Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA.
  • Williams MC; Division of HIV, Infectious Diseases, and Global Medicine, Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA.
  • Arreguin MI; Division of Experimental Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Ngo LH; Division of HIV, Infectious Diseases, and Global Medicine, Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA.
  • Deswal M; Division of HIV, Infectious Diseases, and Global Medicine, Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA.
  • Munter SE; Division of HIV, Infectious Diseases, and Global Medicine, Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA.
  • Martinez EO; Division of HIV, Infectious Diseases, and Global Medicine, Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA.
  • Anglin KA; Division of HIV, Infectious Diseases, and Global Medicine, Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA.
  • Romero MD; Division of HIV, Infectious Diseases, and Global Medicine, Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA.
  • Tavs J; Division of Experimental Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Rugart PR; Division of HIV, Infectious Diseases, and Global Medicine, Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA.
  • Chen JY; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Sans HM; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Murray VW; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Ellis PK; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Donohue KC; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Massachi JA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Weiss JO; Division of Experimental Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Mehdi I; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Pineda-Ramirez J; Division of HIV, Infectious Diseases, and Global Medicine, Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA.
  • Tang AF; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Wenger MA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Assenzio MT; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Yuan Y; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Krone MR; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Rutishauser RL; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Rodriguez-Barraquer I; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Greenhouse B; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Sauceda JA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Gandhi M; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Scheffler AW; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Hsue PY; Division of Experimental Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Henrich TJ; Division of HIV, Infectious Diseases, and Global Medicine, Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA.
  • Deeks SG; Division of HIV, Infectious Diseases, and Global Medicine, Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA.
  • Martin JN; Center for AIDS Prevention Studies, University of California, San Francisco, San Francisco, California, USA.
Open Forum Infect Dis ; 9(2): ofab640, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1672244
ABSTRACT

BACKGROUND:

There is mounting evidence for the presence of postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC), but there is limited information on the spectrum, magnitude, duration, and patterns of these sequelae as well as their influence on quality of life.

METHODS:

We assembled a cohort of adults with a documented history of SARS-CoV-2 RNA positivity at ≥2 weeks past onset of coronavirus disease 2019 (COVID-19) symptoms or, if asymptomatic, first positive test. At 4-month intervals, we queried physical and mental health symptoms and quality of life.

RESULTS:

Of the first 179 participants enrolled, 10 were asymptomatic during the acute phase of SARS-CoV-2 infection, 125 were symptomatic but not hospitalized, and 44 were symptomatic and hospitalized. During the postacute phase, fatigue, shortness of breath, concentration problems, headaches, trouble sleeping, and anosmia/dysgeusia were most common through 8 months of observation. Symptoms were typically at least somewhat bothersome and sometimes exhibited a waxing-and-waning course. Some participants experienced symptoms of depression, anxiety, and post-traumatic stress, as well as difficulties with performance of usual activities. The median visual analogue scale rating of general health was lower at 4 and 8 months compared with pre-COVID-19. Two clusters of symptom domains were identified.

CONCLUSIONS:

Many participants report bothersome symptoms following onset of COVID-19 with variable patterns of persistence and impact on quality of life. The substantial variability suggests the existence of multiple subphenotypes of PASC. A rigorous approach to the prospective measurement of symptoms and functional manifestations sets the stage for the next phase of research focusing on the pathophysiologic causes of the various subgroups of PASC.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Language: English Journal: Open Forum Infect Dis Year: 2022 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Language: English Journal: Open Forum Infect Dis Year: 2022 Document Type: Article Affiliation country: Ofid