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Rapid increase in Omicron infections in England during December 2021: REACT-1 study.
Elliott, Paul; Bodinier, Barbara; Eales, Oliver; Wang, Haowei; Haw, David; Elliott, Joshua; Whitaker, Matthew; Jonnerby, Jakob; Tang, David; Walters, Caroline E; Atchison, Christina; Diggle, Peter J; Page, Andrew J; Trotter, Alexander J; Ashby, Deborah; Barclay, Wendy; Taylor, Graham; Ward, Helen; Darzi, Ara; Cooke, Graham S; Chadeau-Hyam, Marc; Donnelly, Christl A.
  • Elliott P; School of Public Health, Imperial College London, London, UK.
  • Bodinier B; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • Eales O; Imperial College Healthcare NHS Trust, London, UK.
  • Wang H; National Institute for Health Research Imperial Biomedical Research Centre, London, UK.
  • Haw D; Health Data Research (HDR) UK, Imperial College London, London, UK.
  • Elliott J; UK Dementia Research Institute, Imperial College London, London, UK.
  • Whitaker M; School of Public Health, Imperial College London, London, UK.
  • Jonnerby J; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • Tang D; School of Public Health, Imperial College London, London, UK.
  • Walters CE; MRC Centre for Global infectious Disease Analysis and Jameel Institute, Imperial College London, London, UK.
  • Atchison C; School of Public Health, Imperial College London, London, UK.
  • Diggle PJ; MRC Centre for Global infectious Disease Analysis and Jameel Institute, Imperial College London, London, UK.
  • Page AJ; School of Public Health, Imperial College London, London, UK.
  • Trotter AJ; MRC Centre for Global infectious Disease Analysis and Jameel Institute, Imperial College London, London, UK.
  • Ashby D; Imperial College Healthcare NHS Trust, London, UK.
  • Barclay W; Department of Infectious Disease, Imperial College London, London, UK.
  • Taylor G; School of Public Health, Imperial College London, London, UK.
  • Ward H; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • Darzi A; School of Public Health, Imperial College London, London, UK.
  • Cooke GS; National Heart and Lung Institute, Imperial College Healthcare NHS Trust, London, UK.
  • Chadeau-Hyam M; School of Public Health, Imperial College London, London, UK.
  • Donnelly CA; MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Science ; 375(6587): 1406-1411, 2022 03 25.
Article in English | MEDLINE | ID: covidwho-1673338
Preprint
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ABSTRACT
The unprecedented rise in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections during December 2021 was concurrent with rapid spread of the Omicron variant in England and globally. We analyzed the prevalence of SARS-CoV-2 and its dynamics in England from the end of November to mid-December 2021 among almost 100,000 participants in the REACT-1 study. Prevalence was high with rapid growth nationally and particularly in London during December 2021, with an increasing proportion of infections due to Omicron. We observed large decreases in swab positivity among mostly vaccinated older children (12 to 17 years) relative to unvaccinated younger children (5 to 11 years), and in adults who received a third (booster) vaccine dose versus two doses. Our results reinforce the importance of vaccination and booster campaigns, although additional measures have been needed to control the rapid growth of the Omicron variant.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Type of study: Observational study Topics: Vaccines / Variants Limits: Adolescent / Adult / Aged / Child / Child, preschool / Humans / Middle aged Country/Region as subject: Europa Language: English Journal: Science Year: 2022 Document Type: Article Affiliation country: Science.abn8347

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Type of study: Observational study Topics: Vaccines / Variants Limits: Adolescent / Adult / Aged / Child / Child, preschool / Humans / Middle aged Country/Region as subject: Europa Language: English Journal: Science Year: 2022 Document Type: Article Affiliation country: Science.abn8347