Mitochondrial quality surveillance: mitophagy in cardiovascular health and disease.
Am J Physiol Cell Physiol
; 322(2): C218-C230, 2022 02 01.
Article
in English
| MEDLINE | ID: covidwho-1673516
ABSTRACT
Selective autophagy of mitochondria, known as mitophagy, is a major quality control pathway in the heart that is involved in removing unwanted or dysfunctional mitochondria from the cell. Baseline mitophagy is critical for maintaining fitness of the mitochondrial network by continuous turnover of aged and less-functional mitochondria. Mitophagy is also critical in adapting to stress associated with mitochondrial damage or dysfunction. The removal of damaged mitochondria prevents reactive oxygen species-mediated damage to proteins and DNA and suppresses activation of inflammation and cell death. Impairments in mitophagy are associated with the pathogenesis of many diseases, including cancers, inflammatory diseases, neurodegeneration, and cardiovascular disease. Mitophagy is a highly regulated and complex process that requires the coordination of labeling dysfunctional mitochondria for degradation while simultaneously promoting de novo autophagosome biogenesis adjacent to the cargo. In this review, we provide an update on our current understanding of these steps in mitophagy induction and discuss the physiological and pathophysiological consequences of altered mitophagy in the heart.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cardiovascular Diseases
/
Cardiovascular System
/
Reactive Oxygen Species
/
Mitophagy
/
COVID-19
/
Mitochondria
Limits:
Animals
/
Humans
Language:
English
Journal:
Am J Physiol Cell Physiol
Journal subject:
Physiology
Year:
2022
Document Type:
Article
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