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An observational study of hospitalized COVID-19 patients with cancer in San Diego county.
Hermel, David J; Cham, Jason; Spierling Bagsic, Samantha R; Hong, Lee K; Costantini, Carrie L; Mason, James R; Saven, Alan; Sigal, Darren S.
  • Hermel DJ; Division of Hematology & Oncology, Scripps Clinic, La Jolla, CA 92037, USA.
  • Cham J; Division of Hematology & Oncology, Scripps Clinic, La Jolla, CA 92037, USA.
  • Spierling Bagsic SR; Division of Hematology & Oncology, Scripps Clinic, La Jolla, CA 92037, USA.
  • Hong LK; Division of Hematology & Oncology, Scripps Clinic, La Jolla, CA 92037, USA.
  • Costantini CL; Division of Hematology & Oncology, Scripps Clinic, La Jolla, CA 92037, USA.
  • Mason JR; Division of Hematology & Oncology, Scripps Clinic, La Jolla, CA 92037, USA.
  • Saven A; Division of Hematology & Oncology, Scripps Clinic, La Jolla, CA 92037, USA.
  • Sigal DS; Division of Hematology & Oncology, Scripps Clinic, La Jolla, CA 92037, USA.
Future Oncol ; 18(6): 719-725, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1674207
ABSTRACT

Aim:

To delineate clinical correlates of COVID-19 infection severity in hospitalized patients with malignancy.

Methods:

The authors conducted a retrospective review of all hospitalized patients with a hematologic and/or solid tumor malignancy presenting to the authors' institution between 1 March 2020 and 5 January 2021, with a laboratory confirmed diagnosis of COVID-19. Univariate and multivariate logistic regression analyses were used to determine associations between specific severity outcomes and clinical characteristics.

Results:

Among 2771 hospitalized patients with COVID-19, 246 (8.88%) met inclusion criteria. Patients who were actively receiving treatment had an increased rate of death following admission (odds ratio [OR] 2.7). After adjusting for significant covariates, the odds ratio increased to 4.4. Patients with cancer involvement of the lungs had a trend toward increased odds of death after adjusting for covariates (OR 2.3).

Conclusions:

Among COVID-19 positive hospitalized cancer patients, systemic anti-cancer therapy was associated with significantly increased odds of mortality.
Plain language summary Though cancer is a biologically heterogenous disease with a wide spectrum of clinical features and behavior, accumulating evidence suggests that cancer patients are at greater susceptibility to COVID-19 infection and more likely to experience morbidity and mortality from COVID-19 infection than non-cancer patients. In this study, the authors reviewed the clinical characteristics of patients with a diagnosis of cancer hospitalized with COVID-19 to assess potential correlates of COVID-19 severity in this population. Notably, analysis of the hospital data revealed a statistically significant increased incidence of mortality in cancer patients who were receiving systemic anti-cancer treatment, including chemotherapy, immunotherapy or targeted therapy, than in those not on therapy. Likewise, there was a trend toward increased mortality in those with either primary or metastatic tumor involvement of the lung compared with those without lung involvement.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Neoplasms Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: Future Oncol Year: 2022 Document Type: Article Affiliation country: Fon-2021-1116

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Neoplasms Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: Future Oncol Year: 2022 Document Type: Article Affiliation country: Fon-2021-1116