Cell-Free DNA: Potential Application in COVID-19 Diagnostics and Management.
Viruses
; 14(2)2022 02 04.
Article
in English
| MEDLINE | ID: covidwho-1674821
ABSTRACT
WHO has declared COVID-19 as a worldwide, public health emergency. The elderly, pregnant women, and people with associated co-morbidities, including pulmonary disease, heart failure, diabetes, and cancer are the most predisposed population groups to infection. Cell-free DNA is a very commonly applied marker, which is elevated in various pathological conditions. However, it has a much higher sensitivity than standard biochemical markers. cfDNA appears to be an effective marker of COVID-19 complications, and also serves as a marker of certain underlying health conditions and risk factors of severe illness during COVID-19 infection. We aimed to present the possible mechanisms and sources of cfDNA released during moderate and severe infections. Moreover, we attempt to verify how efficiently cfDNA increase could be applied in COVID-19 risk assessment and how it corresponds with epidemiological data.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cell-Free Nucleic Acids
/
SARS-CoV-2
/
COVID-19
Type of study:
Diagnostic study
/
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
Topics:
Long Covid
Limits:
Female
/
Humans
/
Pregnancy
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
V14020321
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