Your browser doesn't support javascript.
Prevalence and clinical characteristics of COVID-19 in inpatients with schizophrenia in Wuhan, China.
Sheng, Hong-Wei; Wang, Hong-Gang; Wang, Chun-Zhi; Wu, Jiang; Huo, Li-Jian; Wang, Ruo-Xi; Zhou, Yong-Jie; Zhang, Xiang-Yang.
  • Sheng HW; Department of Psychiatry, Wuhan Youfu Hospital, Wuhan 430070, Hubei Province, China.
  • Wang HG; Qingdao Mental Health Center, Qingdao University, Qingdao 266000, Shandong Province, China.
  • Wang CZ; Qingdao Mental Health Center, Qingdao University, Qingdao 266000, Shandong Province, China.
  • Wu J; Department of Psychiatry, Wuhan Youfu Hospital, Wuhan 430070, Hubei Province, China.
  • Huo LJ; CAS Key Laboratory of Mental Health, Chinese Academy of Sciences, Beijing 10000, China.
  • Wang RX; Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430070, Hubei Province, China.
  • Zhou YJ; Department of Psychiatric Rehabilitation, Shenzhen Kangning Hospital, Shenzhen 510810, Guangdong Province, China.
  • Zhang XY; CAS Key Laboratory of Mental Health, Chinese Academy of Sciences, Beijing 10000, China. zhangxy@psych.ac.cn.
World J Psychiatry ; 12(1): 140-150, 2022 Jan 19.
Article in English | MEDLINE | ID: covidwho-1675112
ABSTRACT

BACKGROUND:

In contrast to many Western countries, China has maintained its large psychiatric hospitals. The prevalence and clinical characteristics of coronavirus disease 2019 (COVID-19) in inpatients with schizophrenia (SCZ) are unclear.

AIM:

To assess the prevalence of COVID-19 among inpatients with SCZ and compare the infected to uninfected SCZ patients in a Wuhan psychiatric hospital.

METHODS:

We retrospectively collected demographic characteristics and clinical profiles of all SCZ patients with COVID-19 at Wuhan's Youfu Hospital.

RESULTS:

Among the 504 SCZ patients, 84 had COVID-19, and we randomly sampled 174 who were uninfected as a comparison group. The overall prevalence of COVID-19 in SCZ patients was 16.7%. Among the 84 SCZ patients with confirmed COVID-19, the median age was 54 years and 76.2% were male. The most common symptom was fever (82%), and less common symptoms were cough (31%), poor appetite (20%), and fatigue (16%). Compared with SCZ patients without COVID-19, those with COVID-19 were older (P = 0.006) and significantly lighter (P = 0.002), and had more comorbid physical diseases (P = 0.001). Surprisingly, those infected were less likely to be smokers (< 0.001) or to be treated with clozapine (P = 0.03). Further logistic regression showed that smoking [odds ratio (OR) = 5.61], clozapine treated (OR = 2.95), and male (OR = 3.48) patients with relatively fewer comorbid physical diseases (OR = 0.098) were at a lower risk for COVID-19. SCZ patients with COVID-19 presented primarily with fever, but only one-third had a cough, which might otherwise be the most common mode of transmission between individuals.

CONCLUSION:

Two unexpected protective factors for COVID-19 among SCZ inpatients are smoking and clozapine treatment.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: World J Psychiatry Year: 2022 Document Type: Article Affiliation country: Wjp.v12.i1.140

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: World J Psychiatry Year: 2022 Document Type: Article Affiliation country: Wjp.v12.i1.140