Your browser doesn't support javascript.
Outcomes of COVID-19 in Patients with Inflammatory Bowel Disease: Comparison with Household Members and the Role of IBD Medications.
Sima, Ali Reza; Saberzadeh-Ardestani, Bahar; Vahedi, Homayoon; Fakheri, Hafez; Mansour-Ghanaei, Fariborz; Maleki, Iradj; Nasseri-Moghaddam, Siavosh; Vosoghinia, Hasan; Ghadir, Mohammad Reza; Hormati, Ahmad; Kasaeian, Amir; Radmard, Amir Reza; Khosravi, Bardia; Malekzadeh, Masoud; Alatab, Sudabeh; Sadeghi, Anahita; Aminisani, Nayyereh; Poustchi, Hossein; Gonoudi, Elnaz; Anushiravani, Amir; Rayatpisheh, Maryam; Colombel, Jean-Frederic; Ungaro, Ryan C; Malekzadeh, Reza.
  • Sima AR; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Saberzadeh-Ardestani B; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Vahedi H; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Fakheri H; Gut and Liver Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
  • Mansour-Ghanaei F; Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
  • Maleki I; Gut and Liver Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
  • Nasseri-Moghaddam S; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Vosoghinia H; Gastroenterology and Hematology Department, Faculty of Medicine, Ghaem Hospital, Mashhad, Iran.
  • Ghadir MR; Gastroenterology and Hepatology Diseases Research Center, Qom University of Medical Science, Qom, Iran.
  • Hormati A; Gastroenterology and Hepatology Diseases Research Center, Qom University of Medical Science, Qom, Iran.
  • Kasaeian A; Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran.
  • Radmard AR; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Khosravi B; Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Malekzadeh M; Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Alatab S; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Sadeghi A; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Aminisani N; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Poustchi H; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Gonoudi E; Department of Epidemiology and Statistics, Faculty of Health Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran.
  • Anushiravani A; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Rayatpisheh M; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Colombel JF; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Ungaro RC; Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Malekzadeh R; The Henry D. Janowitz Division of Gastroenterology Icahn School of Medicine at Mount Sinai, New York, USA.
Arch Iran Med ; 25(1): 17-25, 2022 01 01.
Article in English | MEDLINE | ID: covidwho-1675644
ABSTRACT

BACKGROUND:

Most data on the effect of inflammatory bowel disease (IBD) and its treatments on coronavirus disease 2019 (COVID-19) outcomes have not had non-IBD comparators. Hence, we aimed to describe COVID-19 outcomes in IBD compared to non-IBD patients.

METHODS:

We conducted a prospective cohort study of registered IBD patients with confirmed COVID-19 from six provinces in Iran from February to April 2020. Proven COVID-19 patients were followed up at four weeks and the frequency of outcomes was assessed. Multivariable logistic regression was used to assess associations between demographics, clinical characteristics and COVID-19 outcomes.

RESULTS:

Overall, 2159 IBD patients and 4721 household members were enrolled, with 84 (3.9%) and 49 (1.1%) participants having confirmed COVID-19, respectively. Household spread of COVID-19 was not common in this cohort (1.2%). While hospitalization was significantly more frequent in IBD patients compared with non-IBD household members (27.1% vs. 6.0%, P=0.002), there was no significant difference in the frequency of severe cases. Age and presence of IBD were positively associated with hospitalization in IBD compared with non-IBD household members (OR 1.06, 95% CI 1.03-1.10; OR 5.7, 95% CI 2.02- 16.07, respectively). Age, presence of new gastrointestinal symptoms, and 5-aminosalicylic acid (5-ASA) use were associated with higher hospitalization rate in IBD patients (OR 1.13, 95% CI 1.05-1.23; OR 6.49, 95% CI 1.87-22.54; OR 6.22, 95% CI 1.90-20.36, respectively). Anti-tumor necrosis factor (TNF) was not associated with more severe outcomes.

CONCLUSION:

Age, presence of new gastrointestinal symptoms and use of 5-ASA were associated with increased hospitalization rate among IBD patients, while anti-TNF therapy had no statistical association.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Inflammatory Bowel Diseases / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Humans Language: English Journal: Arch Iran Med Year: 2022 Document Type: Article Affiliation country: Aim.2022.04

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Inflammatory Bowel Diseases / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Humans Language: English Journal: Arch Iran Med Year: 2022 Document Type: Article Affiliation country: Aim.2022.04