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Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: A living systematic review.
Silveira, Felipe Martins; Mello, André Luiz Rodrigues; da Silva Fonseca, Laura; Dos Santos Ferreira, Luíse; Kirschnick, Laura Borges; Martins, Manoela Domingues; Schuch, Lauren Frenzel; de Arruda, José Alcides Almeida; Soares, Ciro Dantas; de Oliveira Sales, Alexandre; Bologna-Molina, Ronell; Santos-Silva, Alan Roger; Vasconcelos, Ana Carolina Uchoa.
  • Silveira FM; Molecular Pathology Department, School of Dentistry, Universidad de la República, Montevideo, Uruguay; Department of Oral Pathology, School of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
  • Mello ALR; Diagnostic Center for Oral Diseases, School of Dentistry, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil.
  • da Silva Fonseca L; Diagnostic Center for Oral Diseases, School of Dentistry, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil.
  • Dos Santos Ferreira L; Diagnostic Center for Oral Diseases, School of Dentistry, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil.
  • Kirschnick LB; Department of Oral Diagnosis, Piracicaba Dental School, Universidade Estadual de Campinas, Piracicaba, São Paulo, Brazil.
  • Martins MD; Department of Oral Pathology, School of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; Department of Oral Diagnosis, Piracicaba Dental School, Universidade Estadual de Campinas, Piracicaba, São Paulo, Brazil.
  • Schuch LF; Department of Oral Diagnosis, Piracicaba Dental School, Universidade Estadual de Campinas, Piracicaba, São Paulo, Brazil.
  • de Arruda JAA; Department of Oral Surgery, Pathology and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Soares CD; Department of Oral Diagnosis, Piracicaba Dental School, Universidade Estadual de Campinas, Piracicaba, São Paulo, Brazil; Division of Anatomic Pathology, Getulio Sales Diagnósticos, Private Pathology Service, Natal, Rio Grande do Norte, Brazil.
  • de Oliveira Sales A; Division of Anatomic Pathology, Getulio Sales Diagnósticos, Private Pathology Service, Natal, Rio Grande do Norte, Brazil.
  • Bologna-Molina R; Molecular Pathology Department, School of Dentistry, Universidad de la República, Montevideo, Uruguay.
  • Santos-Silva AR; Department of Oral Diagnosis, Piracicaba Dental School, Universidade Estadual de Campinas, Piracicaba, São Paulo, Brazil.
  • Vasconcelos ACU; Diagnostic Center for Oral Diseases, School of Dentistry, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil. Electronic address: carolinauv@gmail.com.
Arch Oral Biol ; 136: 105374, 2022 Apr.
Article in English | MEDLINE | ID: covidwho-1676407
ABSTRACT

OBJECTIVE:

This living systematic review aims to integrate the morphological and tissue-based molecular characterization of oral lesions occurring in individuals infected by COVID-19 (OLICs). MATERIALS AND

DESIGN:

This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Web of Science, Scopus, Ovid, Embase, and LILACS were searched to identify reports on OLICs with morphological and/or tissue-based molecular data.

RESULTS:

Four studies reporting five cases were included. Three patients were male, and the mean age of the individuals was 47.6 years. The most reported anatomical location was the palate (n = 4), whereas ulcers were the most frequent clinical presentation (n = 3). Histopathologically, all cases revealed cell vacuolization and exocytosis in the epithelial layer. In the mesenchymal layer, inflammatory cell infiltrate and thrombi/microvascular thrombosis were observed in three cases. Immunohistochemical reactions were performed in two cases. Both cases were negative for HHV-1, HHV-2, and CMV. One case revealed positivity for SARS-CoV-2 spike protein. No other molecular tests were found for the characterization of OLIC.

CONCLUSIONS:

The pathological characteristics of OLICs are still unspecific. However, with the ongoing COVID-19 pandemic and well-documented new cases, whether OLICs are due to coinfections or has a primary origin can be determined.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Humans / Male / Middle aged Language: English Journal: Arch Oral Biol Year: 2022 Document Type: Article Affiliation country: J.archoralbio.2022.105374

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Humans / Male / Middle aged Language: English Journal: Arch Oral Biol Year: 2022 Document Type: Article Affiliation country: J.archoralbio.2022.105374