Recent advances in the immunopathogenesis of severe asthma.
J Allergy Clin Immunol
; 149(2): 455-465, 2022 02.
Article
in English
| MEDLINE | ID: covidwho-1676782
ABSTRACT
Severe asthma is a heterogeneous disease encompassing different phenotypes and endotypes. Although patients with severe asthma constitute a small proportion of the total population with asthma, they largely account for the morbidity and mortality associated with asthma, indicating a clear unmet need. Being distinct from mild and moderate disease, new insights into the immunopathogenesis of severe asthma are needed. The disease endotypes have provided better insights into the immunopathogenic mechanisms underlying severe asthma. Current stratified approach of treating severe asthma based on phenotypes is met with shortcomings, necessitating unbiased multidimensional endotyping to cope with disease complexity. Therefore, in this review, we explore the distinct endotypes and their mechanistic pathways that characterize the heterogeneity observed in severe asthma.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Asthma
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
J Allergy Clin Immunol
Year:
2022
Document Type:
Article
Affiliation country:
J.jaci.2021.12.765
Similar
MEDLINE
...
LILACS
LIS