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Severe Post-COVID-19 Organizing Pneumonia during Cancer Immunochemotherapy.
Kitahara, Asako; Ebihara, Akinori; Obayashi, Shohei; Horio, Yukihiro; Ono, Yoshitaka; Yoshikawa, Tomohiro; Okada, Naoki; Tanaka, Jun; Takiguchi, Hiroto; Hayama, Naoki; Ito, Yoko; Oguma, Tsuyoshi; Kuwahira, Ichiro; Asano, Koichiro.
  • Kitahara A; Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
  • Ebihara A; Division of Pulmonary Medicine, Department of Medicine, Tokai University Tokyo Hospital, Japan.
  • Obayashi S; Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
  • Horio Y; Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
  • Ono Y; Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
  • Yoshikawa T; Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
  • Okada N; Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
  • Tanaka J; Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
  • Takiguchi H; Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
  • Hayama N; Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
  • Ito Y; Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
  • Oguma T; Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
  • Kuwahira I; Division of Pulmonary Medicine, Department of Medicine, Tokai University Tokyo Hospital, Japan.
  • Asano K; Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
Intern Med ; 61(8): 1219-1223, 2022 Apr 15.
Article in English | MEDLINE | ID: covidwho-2089579
ABSTRACT
A 44-year-old man developed coronavirus disease 2019 (COVID-19) pneumonia during immunochemotherapy consisting of carboplatin, paclitaxel, and pembrolizumab for non-small cell lung cancer. Low-grade fever, followed by mild hypoxemia, and febrile neutropenia, were observed, and granulocyte colony-stimulating factor (G-CSF) was administered until the recovery of neutropenia, when he developed a high fever, severe hypoxemia, and hypotension accompanied by consolidation in the bilateral lungs. His conditions promptly improved after treatment including hydrocortisone and the primary and metastatic tumors remained regressed for 10 months without further treatment. Post-COVID-19 organizing pneumonia during cancer immunochemotherapy can be aggravated by immune-checkpoint inhibitors and G-CSF.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / COVID-19 / Lung Neoplasms Type of study: Case report Topics: Long Covid Limits: Adult / Humans / Male Language: English Journal: Intern Med Journal subject: Internal Medicine Year: 2022 Document Type: Article Affiliation country: Internalmedicine.8928-21

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / COVID-19 / Lung Neoplasms Type of study: Case report Topics: Long Covid Limits: Adult / Humans / Male Language: English Journal: Intern Med Journal subject: Internal Medicine Year: 2022 Document Type: Article Affiliation country: Internalmedicine.8928-21